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Physiological, Morphological and Neurochemical Characterization of Neurons Modulated by Movement
Published on: April 21, 2011
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Movement disorders associated with neuronal antibodies.
1Department of Neurology, All India Institute of Medical Sciences, New Delhi, India.
Acta Neurologica Scandinavica
|October 20, 2018
Summary
Movement disorders linked to neuronal antibodies can be reversed with early treatment. Specific movement patterns may indicate antibody type, aiding diagnosis and improving patient outcomes.
Area of Science:
- Neurology
- Immunology
Background:
- Neuronal antibodies are associated with potentially reversible neurological disorders.
- Movement disorders, including hypokinetic and hyperkinetic involuntary movements, are common clinical features.
Purpose of the Study:
- To review the spectrum of movement disorders associated with neuronal antibodies.
- To highlight how specific movement disorder phenotypes can suggest particular antibodies.
- To discuss treatment strategies for these antibody-associated movement disorders.
Main Methods:
- Literature review of antibodies and associated movement disorders.
- Analysis of distinct movement disorder phenomenology as diagnostic clues.
- Review of current treatment options for antibody-mediated movement disorders.
Main Results:
- The range of movement disorders linked to neuronal antibodies is expanding.
- Specific movement patterns, such as facio-brachial dystonic seizures (LGI-1 antibodies) and orofacial lingual dyskinesia (NMDAR antibodies), are indicative of certain antibodies.
- Early suspicion and targeted antibody testing are crucial.
Conclusions:
- Specific movement disorders can guide the suspicion and testing for particular neuronal antibodies.
- Prompt treatment initiation for antibody-associated movement disorders can lead to better clinical outcomes.
- Increased physician awareness of these conditions is essential for timely intervention.
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