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Calcification of Vascular Smooth Muscle Cells and Imaging of Aortic Calcification and Inflammation
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Calling all calcifications: a retrospective case control study.

Anand K Narayan1, Delia M Keating1, Elizabeth A Morris1

  • 1Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY 10065, USA.

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|October 20, 2018
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Summary
This summary is machine-generated.

Mammography recalls for calcifications are significantly more likely to lead to biopsies than other findings. This highlights the need to consider biopsy rates when interpreting screening mammograms for calcifications.

Keywords:
BiopsyBreast cancerCalcificationsMammographyRecallsScreening

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Area of Science:

  • Radiology
  • Medical Imaging
  • Breast Cancer Screening

Background:

  • Most screening mammography recalls do not result in biopsy recommendations.
  • Understanding factors influencing biopsy decisions is crucial for optimizing screening protocols.

Purpose of the Study:

  • To evaluate if calcifications identified during screening mammography are more likely to lead to biopsy recommendations compared to other mammographic findings.
  • To analyze the impact of recall reasons on subsequent biopsy rates and cancer detection.

Main Methods:

  • Retrospective analysis of screening mammograms with BI-RADS 0 assessment from 2014-2015.
  • Categorization of recall reasons: calcifications, masses, asymmetries, focal asymmetries, and architectural distortions.
  • Logistic regression to compare biopsy recommendation proportions between calcification and non-calcification findings.

Main Results:

  • Calcifications constituted 14.0% of recall findings.
  • Recalls for calcifications were significantly more likely to result in biopsy (Adjusted OR 8.56, p < 0.001) compared to other findings.
  • No significant difference in the positive predictive value of biopsy for cancer (PPV3) was observed between calcification and non-calcification groups.

Conclusions:

  • Mammographic recalls due to calcifications have a substantially higher likelihood of proceeding to biopsy.
  • Clinical practice should consider these increased biopsy rates for calcifications within the context of practice-specific positive predictive values and cancer detection rates.
  • Further research may refine guidelines for managing calcifications detected during mammography screening.