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Aptamer-iRNAs as Therapeutics for Cancer Treatment
Mario M Soldevilla1,2, Daniel Meraviglia-Crivelli de Caso3,4, Ashwathi P Menon5,6
1Molecular Therapy Program, Aptamer Core, Center for the Applied Medical Research (CIMA), University of Navarra (UNAV), 31008 Pamplona, Spain. mmsoldevilla@unav.es.
Aptamers, or specific DNA/RNA molecules, show promise in cancer therapy by delivering interfering RNAs (iRNAs). These aptamer-based agents offer targeted delivery with improved safety and tissue penetration for novel cancer treatments.
Area of Science:
- Biotechnology
- Molecular Biology
- Cancer Therapeutics
Background:
- Aptamers are single-stranded oligonucleotides selected via SELEX for high-affinity target binding.
- Aptamers have emerged as potent therapeutic agents, particularly in oncology.
- Their inherent oligonucleotide nature provides advantages over other therapeutic molecules.
Purpose of the Study:
- To review aptamer-based strategies for delivering interfering RNAs (iRNAs) in cancer therapy.
- To highlight aptamers as targeting and carrier agents for specific iRNA delivery.
- To consolidate recent findings on aptamer-mediated delivery of siRNAs, shRNAs, microRNAs, and ASOs.
Main Methods:
- Literature review focusing on aptamer selection and application in cancer therapy.
- Analysis of studies utilizing aptamers for the targeted delivery of various interfering RNAs.
- Compilation of data on aptamer advantages, including tissue penetrability and safety profiles.
Main Results:
- Aptamers demonstrate significant potential as targeted delivery platforms for cancer therapeutics.
- Aptamer-based delivery systems show enhanced tissue penetration and a favorable safety profile.
- Specific examples of aptamer-mediated delivery of siRNAs, shRNAs, microRNAs, and ASOs in cancer research were identified.
Conclusions:
- Aptamers represent a promising novel platform for targeted cancer therapy.
- Aptamer-based delivery of interfering RNAs offers a versatile approach for drug development.
- Further research into aptamer-mediated delivery holds potential for advancing cancer treatment strategies.
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