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Related Experiment Video

Updated: Feb 3, 2026

Isolating and Imaging Live, Intact Pacemaker Regions of Mouse Renal Pelvis by Vibratome Sectioning

Isolating and Imaging Live, Intact Pacemaker Regions of Mouse Renal Pelvis by Vibratome Sectioning

Published on: April 30, 2021

Nanostim-leadless pacemaker.

Johannes Sperzel¹, Christian Hamm², Andreas Hain²

¹Abteilung für Kardiologie/Elektrophysiologie, Kerckhoff-Klinik GmbH, Benekestr. 2-8, 61231, Bad Nauheim, Germany. J.Sperzel@kerckhoff-klinik.de.

Herzschrittmachertherapie & Elektrophysiologie

|October 21, 2018

Summary

This summary is machine-generated.

The Nanostim was the first leadless pacemaker, with over 1400 implanted. Despite a recall, its concept advanced leadless pacing technology for future devices.

Keywords:

Cardiac resynchronization therapy Implantable defibrillators Leadless pacemaker Nanostim™ study results Safety aspects

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Area of Science:

Cardiology
Biomedical Engineering
Medical Device Technology

Background:

The Nanostim™ was the first self-contained intracardiac pacemaker, marking a significant advancement in cardiac rhythm management.
Between 2013 and 2016, 1423 Nanostim devices were implanted globally, with three clinical trials initiated.

Purpose of the Study:

To review the design, clinical trial results, and long-term experiences with the Nanostim leadless pacemaker.
To discuss lessons learned from Nanostim's successes and failures, applicable to leadless pacemakers generally.
To compare the Nanostim experience with early clinical use of other pioneering device therapies.

Main Methods:

Review of clinical trial data and long-term performance of the Nanostim device.
Analysis of device design, implantation procedures, and patient outcomes.
Comparative analysis with other pioneering cardiac device therapies.

Main Results:

The Nanostim device, despite a recall in 2016 due to rare battery failures, demonstrated the viability of leadless pacing.
The concept has spurred development in dual-chamber, biventricular, and combined defibrillator systems.
Key considerations include minimizing short-term complications through operator training and patient selection, assessing long-term safety, and evaluating device explantation.

Conclusions:

The Nanostim experience provided critical insights into the development and implementation of leadless pacemaker technology.
Lessons learned are crucial for optimizing safety, efficacy, and patient selection for current and future leadless pacing systems.
The pioneering role of Nanostim has paved the way for widespread acceptance and expansion of leadless pacing solutions.