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Immunoglobulin E as a Biomarker in Asthma.
Niharika Rath1, Nikita Raje1, Lanny Rosenwasser2
1Allergy/Immunology, Children's Mercy Hospital, University of Missouri Kansas City School of Medicine, 2401 Gillham Road, Kansas City, MO 64108, USA.
Immunology and Allergy Clinics of North America
|October 22, 2018
Summary
Immunoglobulin E (IgE) is a key biomarker for allergic asthma, aiding in disease management. Biotherapeutics are advancing asthma treatment, with ongoing research into their impact on IgE levels.
Area of Science:
- Allergy and Immunology
- Pulmonology
- Pharmacology
Background:
- Asthma is a prevalent chronic respiratory condition impacting both children and adults, characterized by significant illness and death.
- The multifactorial nature of asthma involves complex interactions between genetic predispositions and environmental influences.
- Immunoglobulin E (IgE) plays a crucial role in specific asthma phenotypes, particularly allergic asthma.
Purpose of the Study:
- To highlight the role of immunoglobulin E (IgE) as a biomarker in asthma management.
- To discuss the emerging importance of biotherapeutics in treating asthma.
- To explore the ongoing research into the effects of biotherapeutics on IgE and its biomarker utility.
Main Methods:
- Review of existing literature on asthma biomarkers.
- Analysis of the role of IgE in different asthma phenotypes.
- Examination of current and emerging biotherapeutic strategies for asthma.
Main Results:
- IgE levels, both total and specific, are valuable indicators in diagnosing and managing allergic asthma.
- Biotherapeutics represent a significant advancement in asthma treatment paradigms.
- Research is actively investigating the relationship between novel biotherapeutics and IgE modulation.
Conclusions:
- IgE serves as a critical biomarker for targeted asthma management, especially in allergic forms.
- Biotherapeutic agents offer promising new avenues for controlling asthma.
- Further research is essential to fully understand the impact of biotherapeutics on IgE and its clinical significance in asthma.
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