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Revisiting the Diabetes-Heart Failure Connection

Markus Wallner1,2,3, Deborah M Eaton2, Dirk von Lewinski1

  • 1Division of Cardiology, Department of Internal Medicine, Medical University of Graz, Graz, Austria.

Current Diabetes Reports
|October 22, 2018
PubMed

Insights

Diabetes and heart failure are closely linked. While standard heart failure treatments work similarly in diabetic patients, the choice of glucose-lowering drugs significantly impacts heart failure outcomes.

Area of Science:

  • Cardiology
  • Endocrinology
  • Pharmacology

Background:

  • Heart failure is a common complication in diabetes mellitus.
  • Diabetes research has historically overlooked heart failure, but recent trials are changing this.
  • Diabetes and heart failure are intertwined, affecting millions globally.

Purpose of the Study:

  • To review clinical data on diabetes and heart failure pathophysiology.
  • To examine the association between glucose control and heart failure.
  • To assess the impact of antihyperglycemic drugs on heart failure outcomes.

Main Methods:

  • Systematic review of current clinical data.
  • Analysis of cardiovascular outcome trials for antihyperglycemic agents.
  • Evaluation of existing heart failure therapies in diabetic patients.

Main Results:

  • Standard heart failure therapies are equally effective in diabetic and non-diabetic patients.
  • Certain antihyperglycemic agents have shown both beneficial and detrimental effects on heart failure hospitalization.
  • Glucose-lowering drug selection critically influences heart failure outcomes.

Conclusions:

  • The interplay between diabetes and heart failure is significant.
  • Antihyperglycemic drug choice is a key factor in managing heart failure in diabetic patients.
  • Further research is needed to optimize cardiovascular outcomes in this population.
Abstract

Keywords:
Antihyperglycemic drugDiabetesHeart failureIncretin-based therapyPathogenesisSGLT-2 inhibitorsTreatment

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