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Revisiting the Diabetes-Heart Failure Connection.
Markus Wallner1,2,3, Deborah M Eaton2, Dirk von Lewinski1
1Division of Cardiology, Department of Internal Medicine, Medical University of Graz, Graz, Austria.
Current Diabetes Reports
|October 22, 2018
Summary
Diabetes and heart failure are closely linked. While standard heart failure treatments work similarly in diabetic patients, the choice of glucose-lowering drugs significantly impacts heart failure outcomes.
Area of Science:
- Cardiology
- Endocrinology
- Pharmacology
Background:
- Heart failure is a common complication in diabetes mellitus.
- Diabetes research has historically overlooked heart failure, but recent trials are changing this.
- Diabetes and heart failure are intertwined, affecting millions globally.
Purpose of the Study:
- To review clinical data on diabetes and heart failure pathophysiology.
- To examine the association between glucose control and heart failure.
- To assess the impact of antihyperglycemic drugs on heart failure outcomes.
Main Methods:
- Systematic review of current clinical data.
- Analysis of cardiovascular outcome trials for antihyperglycemic agents.
- Evaluation of existing heart failure therapies in diabetic patients.
Main Results:
- Standard heart failure therapies are equally effective in diabetic and non-diabetic patients.
- Certain antihyperglycemic agents have shown both beneficial and detrimental effects on heart failure hospitalization.
- Glucose-lowering drug selection critically influences heart failure outcomes.
Conclusions:
- The interplay between diabetes and heart failure is significant.
- Antihyperglycemic drug choice is a key factor in managing heart failure in diabetic patients.
- Further research is needed to optimize cardiovascular outcomes in this population.
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