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[IHC, FISH, CISH, NGS in non-small cell lung cancer: What changes in the biomarker era?]

C Hamard1, X Mignard2, N Pecuchet3

  • 1Service de pneumologie, hôpital Cochin, Assistance publique-Hôpitaux de Paris, 27, rue du Faubourg-St-Jacques, 75014 Paris, France; Inserm UMRS1138, équipe « cancer, immune control and escape », centre de recherche des Cordeliers, Paris Descartes université, 75006 Paris, France.

Revue De Pneumologie Clinique
|October 23, 2018
PubMed

Insights

Lung cancer, a leading cause of death in France, sees advances in targeted therapies and immunotherapy. Biomarker detection through various techniques is crucial for effective lung cancer treatment.

Area of Science:

  • Oncology
  • Biomarker Discovery
  • Thoracic Surgery

Background:

  • Lung cancer is the primary cause of cancer mortality in France, accounting for approximately 30,000 deaths annually.
  • A significant majority (90%) of lung cancer cases are linked to tobacco use.
  • Despite a generally poor prognosis, significant therapeutic progress has been achieved.

Purpose of the Study:

  • To review essential anatomopathology, cytogenetics, and molecular biology techniques for biomarker detection in lung cancer.
  • To highlight the application of these biomarker detection methods in thoracic oncology as of 2018.

Main Methods:

  • Review of established and emerging diagnostic techniques.
  • Focus on anatomopathology, cytogenetics, and molecular biology.
  • Integration of biomarker detection into clinical practice.

Main Results:

  • Targeted therapies and immunotherapy have improved lung cancer treatment outcomes.
  • Biomarker expression is critical for the efficacy of these advanced treatments.
  • Standardized diagnostic tools are necessary for routine biomarker measurement.

Conclusions:

  • Accurate and routine biomarker detection is essential for personalized lung cancer therapy.
  • Advances in diagnostic techniques support the application of targeted therapies and immunotherapy.
  • Continued development in diagnostic tools will further enhance thoracic oncology outcomes.
Keywords:
AnatomopathologieAnatomopathologyBiologie moléculaireBiomarkersBiomarqueursCancer du poumonCytogeneticsCytogénétiqueLung cancerMolecular biology

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