[Brain metastases from uterine leiomyosarcoma].

Area of Science:

• Neuro-oncology
• Pathology
• Medical imaging

Background:

• A 46-year-old female with a history of uterine leiomyosarcoma and radiotherapy presented with acute right-sided sensorimotor deficits.
• Initial clinical examination revealed a right pyramidal syndrome.

Observation:

• Brain magnetic resonance imaging (MRI) identified a left frontoparietal extra-axial aggressive tumor.
• Surgical resection of the cerebral lesion was performed.

Findings:

• Anatomopathological examination revealed fusocellular tumor proliferation with atypical muscle cells, few mitotic figures, and focal necrosis.
• Immunohistochemical analysis confirmed tumor cells positive for anti-h-caldesmon and smooth muscle anti-actin.
• The findings supported a diagnosis of brain metastasis from leiomyosarcoma.

Implications:

• This case highlights the potential for uterine leiomyosarcoma to metastasize to the brain.
• Multimodal treatment including surgery and radiotherapy can lead to positive outcomes in managing brain metastases.
• Accurate diagnosis through advanced imaging and immunohistochemistry is crucial for effective treatment planning.