Related Experiment Video

Updated: Feb 3, 2026

Exosomal miRNA Analysis in Non-small Cell Lung Cancer NSCLC Patients' Plasma Through qPCR: A Feasible Liquid Biopsy Tool
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Exosomal miRNA Analysis in Non-small Cell Lung Cancer NSCLC Patients' Plasma Through qPCR: A Feasible Liquid Biopsy Tool

Published on: May 27, 2016

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Importance of the Keap1-Nrf2 pathway in NSCLC: Is it a possible biomarker?

Raúl Barrera-Rodríguez1

  • 1Department of Biochemistry and Environmental Medicine, National Institute of Respiratory Diseases, Mexico City 14080, Mexico.

Biomedical Reports
|October 23, 2018
PubMed

Insights

Constitutive Nrf2 activation, often due to Keap1 mutations, predicts chemotherapy response in non-small cell lung cancer (NSCLC). Targeting this pathway may improve survival for advanced NSCLC patients.

Area of Science:

  • Oncology
  • Genomics
  • Molecular Biology

Background:

  • Non-small cell lung cancer (NSCLC) is a leading cause of cancer mortality globally.
  • Chemotherapy resistance is a major challenge in treating advanced NSCLC.
  • Alterations in the Keap1-Nrf2 pathway are common in NSCLC.

Purpose of the Study:

  • To review the role of the Keap1-Nrf2 pathway in NSCLC chemotherapy resistance.
  • To explore the potential of Nrf2 as a biomarker for predicting treatment response.
  • To evaluate Nrf2 inhibitors as a therapeutic strategy for NSCLC.

Main Methods:

  • Comparative genomic analyses of NSCLC tumors.
  • Review of literature on Keap1-Nrf2 pathway function and clinical implications.
  • Analysis of Nrf2 activation as a predictor of chemotherapy efficacy.

Main Results:

  • Frequent disruptions in the Keap1-Nrf2 pathway, particularly Keap1 mutations, are observed in NSCLC.
  • Constitutive Nrf2 activation is linked to chemotherapy resistance.
  • Nrf2 mutations are less common than Keap1 mutations.

Conclusions:

  • The Keap1-Nrf2 pathway is crucial in regulating cellular resistance to chemotherapy.
  • Constitutive Nrf2 activation can serve as a predictive biomarker for chemotherapy response in NSCLC.
  • Nrf2 inhibitors represent a potential therapeutic avenue for NSCLC patients with Keap1-Nrf2 mutations.
Keywords:
biomarkerdrug resistancekelch-like ECH-associated protein 1-nuclear factor erythroid-2-related factor-2 pathwaylung cancernon-small cell lung cancer

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