Intelligence Quotient in Patients with Myelomeningocele: A Review

Yusuf Alimi1, Joe Iwanaga2, Rod J Oskouian3

  • 1Anatomy, St. George's University School of Medicine, St. George's, GRD.

Cureus
|October 23, 2018
PubMed

Insights

Children with myelomeningocele (MMC) generally have lower intelligence quotients (IQ). Hydrocephalus and complications like infections further decrease IQ, but prenatal repair may mitigate risks.

Area of Science:

  • Neuroscience
  • Developmental Biology
  • Pediatrics

Background:

  • Myelomeningocele (MMC) is a complex birth defect.
  • The relationship between MMC, hydrocephalus, and cognitive development is debated.
  • Cerebrospinal fluid (CSF) infections and shunt procedures are common in MMC patients.

Purpose of the Study:

  • To review literature on intelligence quotient (IQ) in myelomeningocele (MMC) patients.
  • To investigate the impact of hydrocephalus, infections, and shunt procedures on IQ in MMC.
  • To explore other contributing factors to cognitive development in MMC.

Main Methods:

  • Literature review of studies on myelomeningocele (MMC) and intelligence quotient (IQ).
  • Analysis of factors influencing IQ, including hydrocephalus, CNS infections, and shunt procedures.
  • Consideration of neuroimaging findings and genetic factors.

Main Results:

  • Patients with MMC, with or without complications, exhibit lower IQs compared to controls.
  • Hydrocephalus is associated with a further reduction in IQ among MMC patients.
  • Prenatal repair of MMC may reduce shunt-related complications and their negative impact on IQ.

Conclusions:

  • Cognitive deficits in MMC are multifactorial, influenced by hydrocephalus and treatment-related complications.
  • Further research is needed to identify additional risk and genetic factors affecting MMC and IQ.
  • Early interventions, including prenatal repair, show promise in improving cognitive outcomes.

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