Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Morphogenesis02:19

Morphogenesis

30.4K
Plant morphogenesis—the development of a plant’s form and structure—involves several overlapping developmental processes, including growth and cell differentiation. Precursor cells differentiate into specific cell types, which are organized into the tissues and organ systems that make up the functional plant.
30.4K
Microtubule Instability02:17

Microtubule Instability

6.2K
Microtubules are hollow cylindrical filaments having a diameter of approximately 25 nm and a length that varies from 200 nm to 25 μm. GTP-bound tubulin subunits form αβ-heterodimers for microtubule assembly. These core building blocks interact longitudinally, polymerizing into protofilaments. The protofilaments then interact with one another through lateral bonding forces to form stable cylindrical microtubules. These cylindrical filaments are dynamic as they undergo repeated...
6.2K
The Quantum-Mechanical Model of an Atom02:45

The Quantum-Mechanical Model of an Atom

57.3K
Shortly after de Broglie published his ideas that the electron in a hydrogen atom could be better thought of as being a circular standing wave instead of a particle moving in quantized circular orbits, Erwin Schrödinger extended de Broglie’s work by deriving what is now known as the Schrödinger equation. When Schrödinger applied his equation to hydrogen-like atoms, he was able to reproduce Bohr’s expression for the energy and, thus, the Rydberg formula governing hydrogen spectra.
57.3K
Members Made of Elastoplastic Material01:19

Members Made of Elastoplastic Material

401
The behavior of elastoplastic materials under bending stresses, particularly in structural members with rectangular cross-sections, is crucial for predicting material responses and understanding failure modes. Initially, when a bending moment is applied, the stress distribution across the section follows Hooke's Law and is linear and elastic. This distribution means the stress increases from the neutral axis to the maximum at the outer fibers, up to the elastic limit.
As the bending moment...
401
Genetic Material01:20

Genetic Material

3.7K
Within the human body, a complex and detailed system of trillions of cells works in unison to sustain life. Each cell houses a nucleus, which contains 46 chromosomes divided into 23 pairs. Chromosomes are highly coiled structures made of the genetic material DNA. These chromosomes are essential carriers of genetic information, with half inherited from the mother through her egg and the other half from the father's sperm, combining to create the unique genetic makeup of an individual.
3.7K
Bending of Members Made of Several Materials01:11

Bending of Members Made of Several Materials

612
In analyzing a structural member composed of two different materials with identical cross-sectional areas, it is crucial to understand how their distinct elastic properties affect the member's response under load. The analysis involves assessing stress and strain distributions using the transformed section concept, which accounts for variations in material properties.
Hooke's Law determines stress in each material, stating that stress is proportional to strain but varies due to each material's...
612

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

The mechanical microenvironment and lung stem cell fate.

Frontiers in cell and developmental biology·2026
Same author

Patterns of mitochondrial ATP predict tissue folding.

Science advances·2026
Same author

TGFβ determines epithelial tissue spacing by regulating mesenchymal condensation.

bioRxiv : the preprint server for biology·2026
Same author

Fat promotes growth and invasion in a 3D microfluidic tumor model of triple-negative breast cancer.

APL bioengineering·2026
Same author

Mapping embryonic mouse lung development using enhanced spatial transcriptomics.

bioRxiv : the preprint server for biology·2025
Same author

Fuel, form, and memory: The motility-driven journey of cancer cells.

Current opinion in biomedical engineering·2025

Related Experiment Video

Updated: Feb 3, 2026

Using Synthetic Biology to Engineer Living Cells That Interface with Programmable Materials
10:28

Using Synthetic Biology to Engineer Living Cells That Interface with Programmable Materials

Published on: March 9, 2017

9.6K

Modeling branching morphogenesis using materials with programmable mechanical instabilities.

Andreas P Kourouklis1, Celeste M Nelson1,2

  • 1Department of Chemical & Biological Engineering, Princeton University, Princeton, NJ 08544.

Current Opinion in Biomedical Engineering
|October 23, 2018
PubMed
Summary
This summary is machine-generated.

Branching morphogenesis relies on mechanical forces for tissue development. Engineered soft materials can model these forces, aiding understanding of biological buckling and clefting.

Keywords:
Programmable mechanical instabilitiesbranching morphogenesisbucklingcleftingcreasesmorphodynamicspassive forceswrinkling

More Related Videos

Whole-mount Confocal Microscopy for Adult Ear Skin: A Model System to Study Neuro-vascular Branching Morphogenesis and Immune Cell Distribution
08:42

Whole-mount Confocal Microscopy for Adult Ear Skin: A Model System to Study Neuro-vascular Branching Morphogenesis and Immune Cell Distribution

Published on: March 29, 2018

14.1K
Whole-mount Immunohistochemical Analysis for Embryonic Limb Skin Vasculature: a Model System to Study Vascular Branching Morphogenesis in Embryo
09:53

Whole-mount Immunohistochemical Analysis for Embryonic Limb Skin Vasculature: a Model System to Study Vascular Branching Morphogenesis in Embryo

Published on: May 20, 2011

18.1K

Related Experiment Videos

Last Updated: Feb 3, 2026

Using Synthetic Biology to Engineer Living Cells That Interface with Programmable Materials
10:28

Using Synthetic Biology to Engineer Living Cells That Interface with Programmable Materials

Published on: March 9, 2017

9.6K
Whole-mount Confocal Microscopy for Adult Ear Skin: A Model System to Study Neuro-vascular Branching Morphogenesis and Immune Cell Distribution
08:42

Whole-mount Confocal Microscopy for Adult Ear Skin: A Model System to Study Neuro-vascular Branching Morphogenesis and Immune Cell Distribution

Published on: March 29, 2018

14.1K
Whole-mount Immunohistochemical Analysis for Embryonic Limb Skin Vasculature: a Model System to Study Vascular Branching Morphogenesis in Embryo
09:53

Whole-mount Immunohistochemical Analysis for Embryonic Limb Skin Vasculature: a Model System to Study Vascular Branching Morphogenesis in Embryo

Published on: May 20, 2011

18.1K

Area of Science:

  • Developmental biology
  • Biophysics
  • Materials science

Background:

  • Branching morphogenesis is reproducible across organs and species, despite environmental differences.
  • Regulatory networks integrate mechanical forces and extracellular signals for morphogenetic movements.
  • Cell-generated forces remodel the extracellular matrix (ECM), while passive forces cause tissue buckling and clefting.

Purpose of the Study:

  • To explore the unclear molecular and physical signals driving buckling and clefting in morphogenesis.
  • To highlight engineered soft material systems for modeling these processes.
  • To facilitate understanding of physical mechanisms in branching morphogenesis.

Main Methods:

  • Utilizing engineered soft material systems.
  • Designing materials to display programmable buckles and creases.
  • Modeling physicochemical and spatiotemporal features of buckling and clefting morphogenesis.

Main Results:

  • Soft material systems can be engineered to exhibit programmable buckles and creases.
  • These synthetic materials serve as models for studying buckling and clefting.
  • The study provides insights into the physical mechanisms of morphogenesis.

Conclusions:

  • Engineered soft materials offer a novel approach to study buckling and clefting in branching morphogenesis.
  • Modeling these physical phenomena can enhance our understanding of tissue development.
  • This approach may elucidate conserved mechanisms across diverse organs and species.