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Serum myeloperoxidase concentrations for outcome prediction in acute intracerebral hemorrhage
Guan-Rong Zheng1, Bin Chen1, Jia Shen1
1Department of Neurosurgery, The First People's Hospital of Fuyang District of Hangzhou City, 429 Beihuan Road, Fuyang District, Hangzhou 311400, China.
Background:
Oxidative stress is related to brain injury after spontaneous intracerebral hemorrhage (ICH). Myeloperoxidase (MPO) is a potent oxidizing enzyme. We tested the hypothesis that serum MPO concentrations are increased after ICH and they correlate with stroke severity and outcome.
Methods:
Serum MPO concentrations were measured in 128 ICH patients and 128 controls. Odds ratios of dependent variables, including early neurological deterioration, hematoma growth, 1-week mortality, 6-month mortality, 6-month unfavorable outcome (modified Rankin Scale score > 2) and 6-month overall survival, were calculated and adjusted for age, sex, hematoma volume, National Institutes of Health Stroke Scale (NIHSS) score and vascular risk factors.
Results:
As compared to the controls, the patients had significantly increased serum MPO concentrations. MPO concentrations of the ICH patients were strongly correlated with hematoma volume and NIHSS scores. Serum MPO were independently associated with the above-mentioned study points. Its area under receiver operating characteristic curve was equivalent to those of hematoma volume and NIHSS score. Moreover, serum MPO significantly improved the discriminatory ability of hematoma and NIHSS in predicting 6-month mortality and unfavorable outcome.
Conclusions:
Serum MPO concentrations rise in ICH patients and there is a correlation between MPO concentrations and severity or prognosis.
Insights
Serum myeloperoxidase (MPO) levels are elevated in patients with intracerebral hemorrhage (ICH). Higher MPO concentrations correlate with stroke severity and predict poor outcomes, aiding in prognosis.
Area of Science:
- Neurology
- Biochemistry
- Clinical Medicine
Background:
- Oxidative stress contributes to brain injury following spontaneous intracerebral hemorrhage (ICH).
- Myeloperoxidase (MPO) is a key enzyme involved in oxidative processes.
Purpose of the Study:
- To investigate if serum MPO concentrations increase after ICH.
- To determine the correlation between serum MPO levels, stroke severity, and patient outcomes.
Main Methods:
- Serum MPO levels were measured in 128 ICH patients and 128 controls.
- Statistical analyses, including odds ratios, were performed, adjusting for clinical factors.
- Outcomes assessed included neurological deterioration, hematoma growth, and mortality at various time points.
Main Results:
- ICH patients exhibited significantly higher serum MPO concentrations than controls.
- MPO levels strongly correlated with hematoma volume and NIHSS scores.
- Serum MPO independently predicted stroke severity and 6-month outcomes, improving predictive models.
Conclusions:
- Serum MPO concentrations are elevated in ICH patients.
- MPO levels are associated with ICH severity and prognosis.
- Serum MPO serves as a potential biomarker for predicting outcomes in ICH.
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