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Related Concept Videos

Rapidly Varying Flow01:24

Rapidly Varying Flow

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Rapidly varying flow (RVF) in open channels is characterized by abrupt changes in flow depth over a short distance, with the rate of depth change relative to distance often approaching unity. These flows are inherently complex due to their transient and multi-dimensional nature, making exact analysis difficult. However, approximate solutions using simplified models provide valuable insights into their behavior.Key Features of Rapidly Varying FlowRVF is commonly observed in scenarios involving...
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Substituents on the benzene ring that direct an incoming electrophile to undergo substitution at the meta position are called meta directors. All meta directors either have a positive charge on the atom directly bonded to the ring or a partial positive charge. These groups function by withdrawing electrons from the ring through inductive and resonance effects. Consider the carbocation intermediates formed upon the addition of an electrophile on nitrobenzene at the...
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Updated: Feb 3, 2026

Demonstration of Spin-Multiplexed and Direction-Multiplexed All-Dielectric Visible Metaholograms
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Rapid Multiplexed Detection on Lateral-Flow Devices Using a Laser Direct-Write Technique.

Peijun J W He1, Ioannis N Katis2, Robert W Eason3

  • 1Optoelectronics Research Centre, University of Southampton, Southampton SO17 1BJ, UK. P.He@soton.ac.uk.

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|October 24, 2018
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Summary
This summary is machine-generated.

This study introduces a novel multi-path lateral flow device (LFD) for simultaneous detection of multiple biomarkers. This innovation enhances diagnostic efficiency for point-of-care testing by enabling multiplexed biomarker analysis.

Keywords:
biosensorsinflammation detectionlaser direct-writelateral-flow devicemultiplexed detection

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Area of Science:

  • Biomedical Engineering
  • Analytical Chemistry
  • Point-of-Care Diagnostics

Background:

  • Paper-based lateral flow devices (LFDs) are established low-cost, rapid diagnostic tools for single analyte detection.
  • There is a growing demand for simultaneous detection of multiple analytes in a single sample for comprehensive diagnostics.

Purpose of the Study:

  • To develop a novel multi-path LFD using laser direct-write (LDW) technology for multiplexed detection.
  • To enable simultaneous and individual detection of different analytes without cross-reactivity.

Main Methods:

  • Utilized laser direct-write (LDW) technique to precisely partition a standard LFD's single flow-path into multiple parallel channels.
  • Developed a multi-path LFD capable of independent analyte detection within each channel.
  • Applied the LDW-patterned multi-path LFD for multiplexed detection of C-reactive protein (CRP) and Serum amyloid A-1 (SAA1).

Main Results:

  • Successfully created a multi-path LFD via LDW, enabling simultaneous detection of multiple analytes.
  • Demonstrated multiplexed detection of CRP and SAA1, biomarkers for bacterial infections, within a single LFD.
  • Confirmed no cross-reactivity between analytes in the parallel channels.

Conclusions:

  • The LDW technique effectively creates novel LFDs for multiplexed detection.
  • This multi-path LFD approach offers a more efficient protocol for simultaneous biomarker analysis compared to sequential methods.
  • The developed LFD is suitable for rapid, simultaneous point-of-care diagnosis of conditions like bacterial infections.