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Updated: Feb 3, 2026

Endoscopic Bilateral Nipple-sparing Mastectomy via a Single Axillary Incision with Immediate Pre-pectoral Implant-based Breast Reconstruction
Published on: May 17, 2024
The effect of wound complications following mastectomy with immediate reconstruction on breast cancer recurrence
Stephanie A Valente1, Yitian Liu1, Siddhi Upadhyaya1
1Department of General Surgery, Division of Breast Services, Cleveland Clinic, Cleveland, OH, United States.
Introduction:
The aim of this study was to determine whether complications following mastectomy with immediate breast reconstruction (IBR) were associated with breast cancer recurrence.
Methods:
A retrospective review was performed of women diagnosed with stage I-III breast cancer who underwent mastectomy with IBR between 2005 and 2010. Patient demographics, tumor data, surgical wound complications, treatment details and timing were recorded and analyzed.
Results:
We identified 458 women with a median follow up time of 7.6 years. A total of 22% of patients experienced IBR complications. There was a delay in initiation of adjuvant therapy in patients who had a complication (52 vs 41 days, p < 0.001). There was no significant difference in recurrences between groups with and without complications (p = 0.65).
Conclusions:
In breast cancer patients who undergo mastectomy with IBR, wound complications delayed initiation of adjuvant systemic therapy, but were not associated with an increased risk of cancer recurrence.
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