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Biomarker-Driven and Molecular Targeted Therapies for Hepatobiliary Cancers

William P Harris1, Kit Man Wong1, Supriya Saha2

  • 1Department of Medicine, Division of Medical Oncology, University of Washington, Seattle WA; Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle WA.

Seminars in Oncology
|October 24, 2018
PubMed

Insights

Molecular profiling data is advancing treatments for liver and bile duct cancers. Targeted therapies and immunotherapies show early promise in clinical trials for these hepatobiliary malignancies.

Area of Science:

  • Oncology
  • Molecular Biology
  • Hepatobiliary Medicine

Background:

  • Molecular profiling of hepatobiliary malignancies has rapidly expanded.
  • Hepatocellular carcinoma and biliary tract cancers are significant health concerns.

Purpose of the Study:

  • To review key molecular alterations in common hepatobiliary cancers.
  • To summarize ongoing clinical trials for targeted systemic agents in these cancers.

Main Methods:

  • Review of recent molecular profiling data.
  • Analysis of published and ongoing clinical trial data.

Main Results:

  • Targeted inhibitors and immunotherapeutic agents show promising early clinical results.
  • Identification of key molecular targets in hepatocellular carcinoma and biliary tract cancers.

Conclusions:

  • Molecularly targeted therapies represent a promising new avenue for hepatobiliary cancer treatment.
  • Ongoing clinical trials are crucial for advancing systemic therapy options.
Keywords:
HCCICCbiliary tract cancercholangiocarcinomaclinical trialshepatobiliaryhepatocellular carcinomaimmuno-oncologyimmunotherapyintrahepatic cholangiocarcinomaliver cancermolecular therapysystemic therapytargeted therapeutics

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