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Published on: June 15, 2019
The Relationship Between Sepsis-induced Immunosuppression and Serum Toll-like Receptor 9 Level
Nazan Atalan1, Leyla Acar2, Nihan Yapici3
1Department of Anesthesiology, Marmara University Vocational School of Health Services, Istanbul, Turkey drnazan@hotmail.com.
Background/Aim:
Our aim was to determine serum TLR-9 levels in sepsis and evaluate the relationship between sepsis and serum TLR-9 levels.
Materials And Methods:
The study group consisted of 80 consecutive patients with sepsis and 100 healthy individuals. The demographic characteristics, co-morbidities and hemodynamic data of all patients were recorded.
Results:
TLR-9 serum levels in sepsis were statistically significantly lower compared to the control group. It was also seen that when the lactate level was >5 mmol/l in patients in the sepsis group, the serum TLR-9 levels were substantially higher.
Conclusion:
There is a relationship between sepsis-induced immunosuppression and serum TLR-9 levels. The host immunity system can be activated by means of TLR-9-related systems, while hyperlactatemia may play a stimulating role in the re-activation of the immune system.
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