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Successful implementation of an intracranial hemorrhage (ICH) bundle in reducing severe ICH: a quality improvement
Nicolas Chiriboga1, Josef Cortez2, Adriana Pena-Ariet1
1Division of Neonatology, Department of Pediatrics, University of Florida College of Medicine Jacksonville, Jacksonville, FL, USA.
Insights
A quality improvement initiative significantly reduced severe intracranial hemorrhage (ICH) in preterm infants. The implementation of an ICH bundle in the neonatal intensive care unit (NICU) lowered the incidence of severe ICH by over 50%.
Area of Science:
- Neonatal Medicine
- Pediatric Neurology
- Quality Improvement Science
Background:
- Severe intracranial hemorrhage (ICH) is a significant concern in preterm infants (<30 weeks' gestation).
- Baseline incidence of severe ICH was 24% between January 2012 and December 2013.
- A need existed to implement effective interventions to reduce ICH rates in this vulnerable population.
Purpose of the Study:
- To reduce the incidence of severe ICH in preterm infants.
- To achieve a long-term average ICH rate of 11% by December 2015.
- To evaluate the effectiveness of a multidisciplinary quality improvement initiative.
Main Methods:
- Implementation of an ICH bundle including "golden hour" elements (delayed cord clamping, optimized resuscitation, improved thermoregulation) and clustered care.
- Utilized quality improvement (QI) cycles focusing on bundle initiation, staff education, and sustained adherence.
- Employed statistical process control analysis (p-chart) to monitor ICH rates.
Main Results:
- Severe ICH (grade 3-4) incidence decreased from 24% to a sustained average of 9.7% by December 2017.
- Achieved sustained improvement beyond the initial 2014-2015 goal.
- Observed improved admission temperatures and a significant decrease in mortality rates (14% to 6%).
Conclusions:
- A multidisciplinary QI initiative effectively reduced severe ICH in preterm infants.
- Sustained implementation of the ICH bundle protocol led to a clinically significant reduction in severe ICH.
- The intervention demonstrated positive impacts on infant temperature and mortality.
Objective:
Our specific, measurable, attainable, relevant, and time-limited (SMART) aim was to reduce the incidence of severe intracranial hemorrhage (ICH) among preterm infants born <30 weeks' gestation from a baseline of 24% (January 2012-December 2013) to a long-term average of 11% by December 2015.
Study Design:
We instituted an ICH bundle consisting of elements of the "golden hour" (delayed cord clamping, optimized cardiopulmonary resuscitation, improved thermoregulation) and provision of cluster care in the neonatal intensive care unit (NICU). We identified key drivers to achieve our SMART aims, and implemented quality improvement (QI) cycles: initiation of the ICH bundle, education of NICU staff, and emphasis on sustained adherence. We excluded infants born outside our facility and those with congenital anomalies.
Results:
Using statistical process control analysis (p-chart), the ICH bundle was associated with successful reduction in severe ICH (grade 3-4) in our NICU from a prebundle rate of 24% (January 2012-December 2013) to a sustained reduction over the next 4 years to an average rate of 9.7% by December 2017. Results during 2016-2017 showed a sustained improvement beyond the goal for 2014-2015. Over the same interval, there was improvement in admission temperatures [median 36.1 °C (interquartile range: 35.3-36.7 °C) vs. 37.1 °C (36.8-37.5 °C), p < 0.01] and a decrease in mortality rate [pre: 16/117 (14%) vs. post: 16/281 (6%), P < 0.01].
Conclusion:
Our multidisciplinary QI initiative decreased severe ICH in our institution from a baseline rate of 24% to a lower rate of 9.7% over the ensuing 4 years. Intensive focus on sustained implementation of an ICH bundle protocol consisting of improved delivery room management, thermoregulation, and clustered care in the NICU was temporally associated with a clinically significant reduction in severe ICH.
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