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Updated: Feb 3, 2026

Toluidine Blue Staining of Resin-Embedded Sections for Evaluation of Peripheral Nerve Morphology
Published on: July 3, 2018
Acute edema induced by toluidine blue extravasation-first report
Uwe Wollina1, André Koch2, Birgit Heinig3
1Department of Dermatology and Allergology, Städtisches Klinikum Dresden, Academic Teaching Hospital, Friedrichstraße 41, 01367, Dresden, Germany. Uwe.Wollina@klinikum-dresden.de.
Methemoglobinemia after tumescent anesthesia requires monitoring and potential antidote treatment. Toluidine blue, an effective antidote, can cause complications like painful edema if extravasation occurs.
Area of Science:
- Anesthesiology
- Pharmacology
Background:
- Methemoglobinemia (MetHb) is a condition involving elevated methemoglobin levels in the blood.
- Tumescent anesthesia can lead to increased MetHb levels, necessitating careful patient monitoring.
- Intravenous antidotes are recommended for symptomatic patients or those with MetHb levels exceeding 10%.
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