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Updated: Feb 3, 2026

A Melanoma Patient-Derived Xenograft Model
Published on: May 20, 2019
Method for Generating a Patient-Derived Xenograft Model of CLL
1The Feinstein Institute for Medical Research, Northwell Health System, Manhasset, NY, USA. SChen9@Northwell.edu.
Abstract:
Patient-derived xenograft (PDX) models are created by implantation of tumor cells into immunodeficient mice. These models maintain similar morphology and molecular profiling of the original tumors, and therefore have been extensively used in cancer research in both the basic and preclinical fields. Here, we describe a PDX model of CLL using autologous activated T cells to support CLL B-cell growth in lymphoid tissues such as spleen and bone marrow. This model allows one to perform in vivo preclinical and biological studies for this clinically and molecularly heterogeneous disease.
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