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Related Concept Videos

Neurons: The Cell Body and the Dendrites01:23

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A typical nerve cell comprises three main components: the cell body, dendrites, and the axon. The cell body, also known as the soma or perikaryon, serves as the central biosynthetic hub housing a nucleus surrounded by cytoplasm containing organelles commonly found in most cells. Notably, Nissl bodies, clusters of the rough endoplasmic reticulum and free ribosomes responsible for protein synthesis, are distinctive features of the neuronal cell body. As neurons age, aggregates of a brown pigment...
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Cells are the smallest and basic units of life, whether it is a single cell that forms the entire organism, e.g., in a bacterium or trillions of them, e.g., in humans. No matter what organism a cell is a part of, they share specific characteristics.
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What is Cell Signaling?02:03

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Despite the protective membrane that separates a cell from the environment, cells need the ability to detect and respond to environmental changes. Additionally, cells often need to communicate with one another. Unicellular and multicellular organisms use a variety of cell signaling mechanisms to communicate to respond to the environment.
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Chemistry of the Cell02:58

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The cell is chemically composed of water, organic molecules and inorganic ions.
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The polarity of the water molecule and its resulting hydrogen bonding makes water a unique substance with special properties that are intimately tied to the processes of life. Life originally evolved in an aqueous environment, and most of an organism’s cellular chemistry and metabolism occur inside the aqueous contents of the cell’s cytoplasm. Special properties of water are its high heat capacity...
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Concentration Cells02:41

Concentration Cells

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A concentration cell is a type of a  voltaic cell constructed by connecting two almost identical half-cells, both based on the same half-reaction and using the same electrode, differing only in the concentration of one redox species. A concentration cell's potential, therefore, is determined only by the concentration difference of the particular redox species.
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Hair Cells01:22

Hair Cells

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Hair cells are the sensory receptors of the auditory system—they transduce mechanical sound waves into electrical energy that the nervous system can understand. Hair cells are located in the organ of Corti within the cochlea of the inner ear, between the basilar and tectorial membranes. The actual sensory receptors are called inner hair cells. The outer hair cells serve other functions, such as sound amplification in the cochlea, and are not discussed in detail here.
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Fluorescence-activated Cell Sorting for Purification of Plasmacytoid Dendritic Cells from the Mouse Bone Marrow
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Blastic Plasmacytoid Dendritic Cell Neoplasm.

Joseph D Khoury1

  • 1Department of Hematopathology, The University of Texas M.D. Anderson Cancer Center, 1515 Holcombe Boulevard, MS-072, Houston, TX, 77030, USA. jkhoury@mdanderson.org.

Current Hematologic Malignancy Reports
|October 24, 2018
PubMed
Summary
This summary is machine-generated.

Blastic plasmacytoid dendritic cell neoplasm (BPDCN) is a rare cancer. TCF4 is a key regulator, and inhibiting BRD4 offers a promising treatment strategy for BPDCN.

Keywords:
Acute leukemiaBlastic plasmacytoid dendritic cell neoplasmCD123Flow cytometryPlasmacytoid dendritic cellsTCF4

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Area of Science:

  • Hematology
  • Oncology
  • Molecular Biology

Background:

  • Blastic plasmacytoid dendritic cell neoplasm (BPDCN) is a rare hematologic malignancy.
  • Understanding BPDCN biology, clinical features, and treatment is rapidly advancing.

Purpose of the Study:

  • To review current understanding of BPDCN biology, diagnostics, and therapeutics.
  • To highlight TCF4 as a master regulator and BRD4 as a therapeutic target.

Main Methods:

  • Review of recent scientific literature on BPDCN.
  • Analysis of gene expression profiles and genomic landscape.
  • Evaluation of diagnostic markers and therapeutic vulnerabilities.

Main Results:

  • TCF4 is a critical regulator in BPDCN, with its activity dependent on BRD4.
  • BRD4 inhibition presents a potential therapeutic strategy.
  • TCF4 expression is a sensitive diagnostic marker for BPDCN.
  • Genomic landscape includes alterations in ETV6, MYC, NR3C1, and TET2 mutations.
  • Aberrant NF-kappaB pathway activation is characteristic.

Conclusions:

  • Advances in understanding BPDCN biology are refining diagnostics.
  • Novel therapeutic avenues are emerging for BPDCN patients.
  • Targeting TCF4-BRD4 axis offers promising treatment strategies.