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Catalytic Asymmetric Conjugate Arylation of γ,δ-Unsaturated β-Dicarbonyl Compounds
Jian Yao1, Long Yin1, Yue Shen1
1Department of Organic Chemistry, School of Science , China Pharmaceutical University , 639 Longmian Avenue , Nanjing 211198 , China.
Abstract:
The first catalytic asymmetric conjugate addition to γ,δ-unsaturated β-dicarbonyl compounds was developed. With a chiral diene-rhodium(I) μ-chloro dimer as the catalyst in toluene/H2O, asymmetric conjugate arylation of γ,δ-unsaturated β-dicarbonyl compounds with arylboronic acids proceeded in high efficiency with excellent enantioselectivities. The generated β-dicarbonyl products are versatile chiral synthons, which can be easily converted to diverse important chiral structures.
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