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Enhanced angiotensinogen expression in neonates during kidney development.

Miki Shono1, Maki Urushihara2, Kenichi Suga1

  • 1Department of Pediatrics, Institute of Biomedical Sciences, Tokushima University Graduate School, Kuramoto-cho 3-18-15, Tokushima, Tokushima, 770-8503, Japan.

Clinical and Experimental Nephrology
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Preterm neonates show higher urinary angiotensinogen (AGT) levels, indicating enhanced renin-angiotensin system (RAS) activation during kidney development. This supports the link between in utero development and neonatal RAS status.

Keywords:
AngiotensinogenKidney developmentNeonatesRenin–angiotensin system

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Area of Science:

  • Neonatal physiology
  • Renal development
  • Cardiovascular research

Background:

  • Preterm neonates exhibit elevated urinary angiotensinogen (AGT) levels compared to full-term neonates.
  • Investigated the association between heightened neonatal AGT expression and intrarenal renin-angiotensin system (RAS) status during kidney development.

Purpose of the Study:

  • To test the hypothesis that enhanced neonatal AGT expression correlates with intrarenal RAS status during kidney development.
  • To analyze the relationship between gestational age, urinary AGT levels, and renal AGT expression in neonates.

Main Methods:

  • Prospective recruitment of neonates and healthy children.
  • Measurement of plasma and urinary AGT levels at birth and 1 year.
  • Immunohistochemical (IHC) analysis of renal AGT expression in kidney tissues.

Main Results:

  • Urinary AGT levels decreased significantly by 1 year after birth.
  • Urinary AGT levels at birth were inversely correlated with gestational age.
  • Renal AGT expression was higher in neonates than in healthy children and inversely correlated with gestational age.

Conclusions:

  • Elevated AGT expression and urinary excretion in neonates suggest intrarenal RAS activation.
  • This activation is likely associated with the process of kidney development in utero.
  • Findings provide insights into the developmental origins of RAS-related conditions.