Related Experiment Video
Updated: Feb 3, 2026

A Zebrafish Embryo Model for In Vivo Visualization and Intravital Analysis of Biomaterial-associated Staphylococcus aureus Infection
Published on: January 7, 2019
Experimental Cardiomyogenesis Under Conditions of Administration of Different Doses of the Allogeneic Biomaterial
A I Lebedeva1, S A Muslimov2, E M Gareev2
1All-Russian Center for Eye and Plastic Surgery, Ministry of Health of the Russian Federation, Ufa, Republic of Bashkortostan, Russia. jeol02@mail.ru.
Abstract:
We studied the effect of different concentrations of the allogeneic biotransplant on myocardial recovery. In Wistar rats, coronary artery was ligated and intramyocardial injection of 12 or 24 mg Alloplant biomaterial suspension was performed. Histological analysis was conducted on paraffin sections stained by Mallory. The index of the scar area was measured on preparations of transverse sections of the hearts. Allogeneic biomaterial produced cardioprotective and regenerative effect in the myocardium damaged by ischemia. After administration of Alloplant in a dose of 12 mg, the index of scar area decreased by 2.74 times; after doubling the Alloplant dose (24 mg), the index of scar area decreased by 26 times.
Related Concept Videos
Dose Size and Dosing Frequency: Determination Methods
Determination of Multiple Dosing Parameters: Loading and Maintenance Doses
Rational Dosage Regimen: Maintenance Dose and Loading Dose
In most cases, drugs are administered repetitively or infused continuously to maintain a steady-state concentration in the body. At a steady...
Dose-Response Relationship: Overview
Drug Dosing: Infants and Children
Drug Dosing: Geriatric Patients

