Related Experiment Video
Updated: Feb 3, 2026

Synthesis and Reaction Chemistry of Nanosize Monosodium Titanate
Published on: February 23, 2016
Synthesis of Glycomimetics by Diastereoselective Passerini Reaction
Kristina Vlahoviček-Kahlina1, Mario Vazdar1, Andreja Jakas1
1Ruđer Bošković Institute , Division of Organic Chemistry and Biochemistry , Bijenička cesta 54 , 10000 Zagreb , Croatia.
Abstract:
We describe the utilization of bis-isopropylidene-protected d-fructose-derived aldehyde in the Passerini reaction with various acids and isocyanides. A library of densely functionalized glycomimetics bearing up to 3 carbohydrate units was obtained in high yields and diastereoselectivities. The configuration of the newly formed stereocenter was determined and the diastereoselectivity was rationalized by DFT calculations.
Related Concept Videos
Synthesis and Decomposition Reactions
Reaction Stoichiometry
Synthesis of α-Substituted Carbonyl Compounds: The Stork Enamine Reaction
Dehydration Synthesis
Dehydration synthesis (also called a condensation reaction) is the chemical process in which two molecules covalently link together to form a new molecule, along with the release of a water molecule. Many physiologically important compounds form by dehydration synthesis reactions, such as complex carbohydrates, proteins, DNA, and RNA.
Synthesis of carbohydrates
Sugar molecules are covalently linked together by dehydration synthesis. During the reaction, the hydroxyl (-OH) group from...
Lagging Strand Synthesis
There are several major differences between synthesis of the leading strand and synthesis of the lagging strand. 1) Leading strand synthesis happens in the direction of replication fork opening, whereas lagging strand synthesis happens in the...
Reaction Mechanisms
For instance, the decomposition of ozone appears to follow a mechanism with two steps:

