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Minimally Invasive Thumb-sized Pterional Craniotomy for Surgical Clip Ligation of Unruptured Anterior Circulation Aneurysms
Published on: August 11, 2015
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Association Between Unruptured Intracranial Aneurysms and Downstream Stroke
Monica Lin Chen1, Ajay Gupta1,2, Abhinaba Chatterjee1
1From the Clinical and Translational Neuroscience Unit, Feil Family Brain and Mind Research Institute (M.L.C., A.G., A.C., D.K., G.G., A.E.M., B.B.N., H.K.).
Stroke
|October 26, 2018
Summary
This study found no significant link between unruptured intracranial aneurysms and ipsilateral ischemic stroke. Our research indicates aneurysms do not increase the risk of stroke on the same side of the brain.
Area of Science:
- Neurology
- Vascular Neurology
- Neuroimaging
Background:
- Case reports suggest unruptured intracranial aneurysms may cause thrombus formation and embolic stroke.
- Limited data exist to confirm an association between unruptured aneurysms and ischemic stroke.
Purpose of the Study:
- To investigate the association between unruptured intracranial aneurysms and acute ischemic stroke.
- To determine if aneurysms ipsilateral to infarcts are more prevalent than contralateral aneurysms.
Main Methods:
- A within-subjects case-control study of acute ischemic stroke patients.
- Used magnetic resonance imaging and arterial imaging within 14 days of admission.
- Compared aneurysm prevalence ipsilateral versus contralateral to anterior circulation infarcts using McNemar test.
Main Results:
- 176 of 1541 patients (11.4%) had an intracranial aneurysm.
- Aneurysm prevalence did not differ ipsilateral versus contralateral to infarction (Risk Ratio [RR], 1.2; 95% CI, 0.9-1.5).
- No significant association found in secondary analyses for single territory, cryptogenic, or cryptogenic single territory strokes.
Conclusions:
- Contrary to hypothesis, no significant association was found between unruptured intracranial aneurysms and ipsilateral ischemic stroke.
- Findings suggest unruptured aneurysms may not be a direct cause of ischemic stroke in the anterior circulation.
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