Related Experiment Video
Updated: Feb 3, 2026
06:58
Frailty Assessment in an Aging Mouse Model
Published on: September 23, 2025
596
Mouse Models to Disentangle the Hallmarks of Human Aging
Alicia R Folgueras1, Sandra Freitas-Rodríguez1, Gloria Velasco1
1From the Departamento de Bioquímica y Biología Molecular, Facultad de Medicina, Instituto Universitario de Oncología del Principado de Asturias, Universidad de Oviedo, Spain.
Circulation Research
|October 26, 2018
Summary
Genetically modified mouse models reveal key aging hallmarks and interventions. This research identifies promising anti-aging strategies by studying lifespan extension and aging acceleration in vivo.
Area of Science:
- Gerontology and genetics
- Molecular biology of aging
Background:
- Model organisms demonstrate aging can be delayed, extending lifespan.
- Aging research focuses on understanding complex biological pathways and networks.
- The 9 hallmarks of aging provide a framework for analysis.
Purpose of the Study:
- To review the 9 hallmarks of aging.
- To analyze data exclusively from genetically modified mouse models.
- To identify promising anti-aging interventions.
Main Methods:
- Review of existing literature on aging hallmarks.
- Focus on genetically modified mouse models.
- Analysis of interventions affecting aging and lifespan.
Main Results:
- Genetically modified mouse models are crucial for aging research.
- Specific interventions can accelerate or extend lifespan.
- Interconnections between aging hallmarks are evident.
Conclusions:
- Mouse models offer critical insights into aging processes.
- Understanding aging hallmarks guides the development of anti-aging strategies.
- Further research in vivo models will refine anti-aging approaches.
Related Concept Videos
01:26Aging
703
Aging is a complex biological phenomenon influenced by various processes that affect cellular and systemic functions. Several prominent theories attempt to explain its mechanisms, highlighting cellular limitations, oxidative damage, and hormonal changes as central factors in aging.
Cellular Clock Theory
The cellular clock theory posits that the human lifespan is closely tied to the finite capacity of cells to divide, a phenomenon governed by telomeres, which are protective caps at the ends of...
Cellular Clock Theory
The cellular clock theory posits that the human lifespan is closely tied to the finite capacity of cells to divide, a phenomenon governed by telomeres, which are protective caps at the ends of...
703
01:19The Effect of Aging on Tissues
3.5K
Several body functions deteriorate with age. The external signs of aging are easily identifiable. For example, the skin becomes dry, less elastic, and thins out, forming wrinkles. The skin of the face begins to appear looser due to a decrease in the levels of elastic and collagen fibers in the connective tissue. Additionally, melanin production in the hair follicle decreases with age, resulting in gray hair. Moreover, the senses of sight and hearing decline, so glasses and hearing aids may...
3.5K
01:09Changes in the Appendicular Skeleton with Age
3.5K
The upper and lower limb initially develops as a small bulge called a limb bud, which appears on the lateral side of the early embryo. The upper limb bud appears near the end of the fourth week of development, with the lower limb bud appearing shortly after.
Initially, the limb buds consist of a core of mesenchyme covered by a layer of ectoderm. The ectoderm at the end of the limb bud thickens to form a narrow crest called the apical ectodermal ridge. This ridge stimulates the underlying...
Initially, the limb buds consist of a core of mesenchyme covered by a layer of ectoderm. The ectoderm at the end of the limb bud thickens to form a narrow crest called the apical ectodermal ridge. This ridge stimulates the underlying...
3.5K
02:43Mouse Models of Cancer Study
6.6K
Mice have long served as models for studying human biology and pathology because of their phylogenetic and physiological similarity with humans. They are also easy to maintain and breed in the laboratory, and hence, many inbred strains are now available for research. Studies on mice have contributed immeasurably to our understanding of cancer biology.
The development of transgenic, knockout, and knock-in mice has led to an exponential increase in their use as model organisms in research,...
The development of transgenic, knockout, and knock-in mice has led to an exponential increase in their use as model organisms in research,...
6.6K
01:27Pharmacodynamics in Geriatric Patients: Effects of Age
237
Age-related pharmacokinetic changes are extensively documented, but understanding age-related pharmacodynamic alterations is relatively limited. This knowledge gap can be partly attributed to the complexity of developing appropriate measures of drug responses compared to bioanalytical methods for determining drug concentrations.Most information regarding age-related differences in human pharmacodynamics originates from cross-sectional studies. However, these studies assume that observed mean...
237
01:22Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Absorption
701
As individuals age, their body's physiology evolves, affecting drug pharmacokinetics. The most apparent changes occur in the gastrointestinal tract, where an increase in gastric pH, a delay in gastric emptying, and a reduction in gastrointestinal motility are observed. Remarkably, these changes do not substantially modify the absorption of orally administered drugs, particularly those absorbed via passive diffusion.Transdermal drug delivery emerges as a highly viable method for older adults due...
701