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Nucleotide sequence and evolution of ETn elements.

P Sonigo, S Wain-Hobson, L Bougueleret

    Proceedings of the National Academy of Sciences of the United States of America
    |June 1, 1987
    PubMed
    Summary
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    Early transposons (ETn) are abundant in early mouse embryos and transcribed from retroviral-like elements. Despite lacking homology to retroviral proteins, ETn sequences show concerted evolution across mouse species.

    Area of Science:

    • Genetics
    • Molecular Biology
    • Developmental Biology

    Background:

    • Early transposons (ETn) are repetitive DNA sequences found in eukaryotic genomes.
    • These sequences are often transcribed during early embryonic development.
    • Their origin and evolutionary mechanisms are not fully understood.

    Purpose of the Study:

    • To characterize the ETn family of sequences in mouse embryos.
    • To investigate the transcriptional activity and genomic distribution of ETn elements.
    • To explore the evolutionary dynamics of ETn sequences within and across mouse species.

    Main Methods:

    • Nucleotide sequencing of ETn elements.
    • Analysis of transcriptional abundance in early mouse embryos.
    • Southern blotting to assess genetic polymorphism across mouse species.

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    Main Results:

    • ETn sequences are abundantly transcribed in early mouse embryos.
    • Sequencing revealed no long open reading frames or homology to retroviral proteins.
    • Genetic polymorphism analysis indicated a concerted mode of evolution for ETn sequences.

    Conclusions:

    • ETn elements are a significant component of the early mouse embryonic transcriptome.
    • The evolutionary trajectory of ETn sequences suggests coordinated regulation or selection.
    • Further research is needed to elucidate the functional role and origin of ETn elements.