Related Experiment Video
Updated: Feb 3, 2026
07:16
Isolation of Cancer Stem Cells From Human Prostate Cancer Samples
Published on: March 14, 2014
14.6K
Obesity is Associated with Upgrading in Prostate Cancers
Mustafa Sungur1, Selahattin Çalışkan1
1Department of Urology, Çorum Training and Research Hospital, Hitit University, Çorum, Turkey.
Folia Medica
|October 26, 2018
Summary
Obesity is linked to younger age and higher PSA levels at prostate cancer diagnosis. Obese men show higher rates of high-grade, advanced prostate cancer and upgrading after surgery.
Area of Science:
- Urology
- Oncology
- Public Health
Background:
- Prostate cancer (PCa) is a leading cause of cancer death in men globally.
- Emerging evidence suggests a correlation between obesity and PCa.
- Understanding this link is crucial for patient outcomes.
Purpose of the Study:
- To evaluate the effect of obesity on the oncological results following radical prostatectomy.
- To determine if body mass index (BMI) influences postoperative outcomes in PCa patients.
Main Methods:
- Retrospective analysis of 101 patients undergoing radical prostatectomy (2011-2016).
- Patients categorized into normal (BMI<25), overweight (25-29.9), and obese (BMI>30) groups.
- Data collected included age, PSA, biopsy, and pathological results.
Main Results:
- Obese patients were younger at diagnosis with higher PSA levels.
- Higher proportions of locally advanced disease and high-grade PCa observed in obese individuals.
- Significant association found between obesity and tumor upgrading in final pathology reports.
Conclusions:
- Obesity is associated with adverse pathological features in prostate cancer.
- Obese men diagnosed with PCa exhibit poorer prognostic indicators.
- BMI is a significant factor influencing postoperative outcomes and tumor characteristics.
Related Concept Videos
01:24Obesity
1.3K
The Body Mass Index (BMI) is a numerical value derived from a person's weight and height, used to categorize individuals into weight ranges. It is calculated using the formula: weight in kilograms divided by height in meters squared. Obesity is a health condition characterized by excessive accumulation of adipose tissue that poses health risks, often diagnosed with a BMI ≥ 30. This excess fat storage occurs when surplus dietary calories are converted into triglycerides and stored in...
1.3K
01:21Drug Dosing: Obese Patients
263
In the United States, obesity is a prominent concern. It is linked to heightened mortality rates due to increased occurrences of conditions such as hypertension, atherosclerosis, coronary artery disease, and diabetes compared to nonobese individuals. A patient is classified as obese if their actual body weight surpasses the ideal or desirable body weight by 20%, based on Metropolitan Life Insurance Company data. Ideal body weights consider average weights and heights for males and females...
263
01:25Pharmacokinetics in Obese Patients: Drug Absorption and Distribution
282
Obesity significantly alters the pharmacokinetic processes of drug absorption and distribution, presenting unique challenges in medical treatment. The increased fat tissue and decreased lean muscle in obese individuals can significantly affect how drugs are absorbed into the body and distributed across different tissues. This alteration can lead to variances in the effectiveness and safety of medications, necessitating adjustments in dosing or drug selection for obese patients.One notable...
282
01:20Pharmacokinetics in Obese Patients: Drug Metabolism and Excretion
184
Drug metabolism, a critical process in the liver, involves two primary phases: Phase I reactions and Phase II conjugation. Obesity introduces significant alterations in this metabolic process, primarily due to fatty infiltration of the liver, leading to conditions such as nonalcoholic fatty liver disease (NAFLD). This condition can modify the activities of both Phase I and II enzymes, impacting how drugs are metabolized in obese patients.Phase I metabolism sees variable effects across...
184
02:18Cancer
54.3K
Cancers arise due to mutations in genes involved in the regulation of cell division, which leads to unrestricted cell proliferation. Modern science and medicine have made great strides in the understanding and treatment of cancer, including eradicating cancer in some patients. However, there is still no cure for cancer. This is largely due to the fact that cancer is a large group of many diseases.
54.3K
02:12What is Cancer?
14.4K
Cells and tissues must meticulously coordinate their activities for the normal functioning of the human body. Therefore, they exhibit socially responsible behavior - resting, growing, dividing, differentiating, or dying - for the organism’s benefit. Cancer arises when cells divide uncontrollably and invade other tissues or organs.
Although people have known about cancer for centuries, it was only in 1761 that Giovanni Morgagni of Padua performed a detailed autopsy of...
Although people have known about cancer for centuries, it was only in 1761 that Giovanni Morgagni of Padua performed a detailed autopsy of...
14.4K