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A Model for Trans-Kingdom Pathogenicity in Fonsecaea Agents of Human Chromoblastomycosis

Gheniffer Fornari1, Renata Rodrigues Gomes1, Juliana Degenhardt-Goldbach2

  • 1Microbiology, Parasitology and Pathology Post-graduation Program, Department of Basic Pathology, Federal University of Paraná, Curitiba, Brazil.

Frontiers in Microbiology
|October 26, 2018
PubMed

Insights

This study compared fungal pathogens causing chromoblastomycosis with plant-associated fungi. It found differences in host colonization and pathogenicity, revealing insights into trans-kingdom fungal infections.

Area of Science:

  • Mycology
  • Pathogen Biology
  • Plant Pathology

Background:

  • The fungal genus *Fonsecaea* causes human chromoblastomycosis, a chronic skin infection.
  • Infection is hypothesized to occur via plant material.
  • Understanding trans-kingdom pathogenicity is crucial.

Purpose of the Study:

  • To evaluate infection models in plant and animal hosts.
  • To compare clinical *Fonsecaea* strains with a plant-isolated strain (*F. erecta*).
  • To understand parameters of trans-kingdom pathogenicity.

Main Methods:

  • Infection assays in plant tissues.
  • Infection model using *Tenebrio molitor* larvae.
  • Immunologic assay in BALB/c mice.

Main Results:

  • Clinical strains (*F. monophora*, *F. pedrosoi*) stayed near plant epidermis; *F. erecta* showed endophytic behavior.
  • *F. erecta* reduced survival in invertebrate models.
  • *F. pedrosoi* formed muriform cells in animal models, indicating pathogenic adaptation.

Conclusions:

  • *Fonsecaea* species exhibit distinct host colonization strategies.
  • Muriform cell formation is a pathogenic adaptation in animal tissues.
  • Host immune response can control virulence of saprobic fungal species.
Keywords:
Bactris gasipaesFonsecaeaMimosa pudicaTenebrio molitoranimal modelchromoblastomycosisplant modelvirulence

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