[Specific dynamic action of food in obese patients]

Certain features of the body hormonal system participation in the realizing of the specific dynamic action of food (SDAF) were studied in 26 patients with exogenous constitutional obesity. The radioimmunoassay was used to estimate the levels of a number of hormones (gastrin, insulin, glucagon, triiodothyronine, thyrotrophin, adrenocorticotrophin and hydrocortisone) in the peripheral blood of the patients on an empty stomach (the basal level) and 1,2 and 4 hours after food protein intake. The control group consisted of 20 normal subjects. It has been shown that SDAF is a complex process of changing from the state of hunger to satiation that involves many regulatory components, both nervous and humoral. The study of the features of the SDAF development in health and disease presents valuable information on the mechanisms of metabolic disorders in the body in varying pathologic states including obesity.