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Different expressions of miR-125b and SOX30 in malignant lymphomas and their significance
Chengzhi Zhan1, Tao Wang, Hua You
1Department of Pathology, Xianning Central Hospital, the First Affiliated Hospital of Hubei University of Science and Technology, Xianning, China.
Purpose:
To explore the roles of micro RNAs (miRs)-125b and SOX30 in malignant lymphomas.
Methods:
The correction of miR-125b targeting SOX30 was examined by the luciferase reporter assay. The expression levels of miR-125b and SOX30 were tested by in situ hybridization and immunohistochemistry.
Results:
miR-125b was able to bind to the 3'UTR of SOX30 gene and was negatively associated with SOX30. As compared with the reactive hyperplasia lymphatic samples, the higher (miR-125b) and lower (SOX30) rate was expressed positively in the malignant lymphomas, which was related to the stage and grade of malignancy.
Conclusions:
miR-125b can regulate SOX30 by binding to its 3'UTR. miR-125b and SOX30 act as diagnostic and therapeutic markers for malignant lymphoma.
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