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Updated: Feb 3, 2026

Determining Membrane Protein Topology Using Fluorescence Protease Protection FPP
Published on: April 20, 2015
Vibrational Energy in Proteins Correlates with Topology
L Maggi1, P Carloni1,2,3,4, G Rossetti1,5,6
1Computational Biomedicine Section, Institute of Advanced Simulation IAS-5 and Institute of Neuroscience and Medicine INM-9 , Forschungszentrum Jülich GmbH , 52425 Jülich , Germany.
Abstract:
The exchange of vibrational energy in proteins is crucial for their function. Here, we establish a connection between quantities related to it with geometry-based properties such as the proteins' residues coordination number. This relation is proven by molecular simulation in a neuro-pharmacologically relevant transmembrane receptor. The connection demonstrated here paves the way to studies of protein allostery and conformational changes based solely on protein structure.
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