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Updated: Feb 3, 2026

Establishing a Mouse Model of Thin Endometrium
Published on: November 1, 2024
Telomerase Reverse Transcriptase Expression in Mouse Endometrium During Reepithelialization and Regeneration in a
Fiona L Cousins1,2, Dorien F O1, Yih Rue Ong1
11 The Ritchie Centre, Hudson Institute of Medical Research, Clayton, Australia.
Abstract:
The regenerative capacity of the endometrium has been attributed to resident stem/progenitor cells. A number of stem/progenitor markers have been reported for human endometrial stem/progenitor cells; however, the lack of convenient markers in the mouse has made experimental investigation into endometrial regeneration difficult. We recently identified endometrial epithelial, endothelial, and immune cells, which express a reporter for the stem/progenitor marker, mouse telomerase reverse transcriptase (mTert). In this study, we investigate the expression pattern of a green fluorescent protein (GFP) reporter for mTert promoter activity (mTert-GFP) in endometrial regeneration following a menses-like event. mTert-GFP expression marks subepithelial populations of T cells and mature macrophages and may play a role in immune cell regulated repair. Clusters of mTert-GFP-positive epithelial cells were identified close to areas of reepithelialization and possibly highlight a role for mTert in the repair and regeneration of the endometrial epithelium.
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