CORRELATION OF RED BLOOD FACTORS IN POLYTRAUMA INDUCED SEPSIS AND SEPTIC SHOCK PATIENTS

Area of Science:

• Critical Care Medicine
• Hematology
• Pathophysiology

Background:

• Polytrauma and sepsis/septic shock patients often develop anemia, impacting patient outcomes.
• Early diagnosis and monitoring of anemia are crucial for managing these critically ill patients.
• Understanding the interplay between red blood cell dynamics and inflammation is vital for treatment selection and prognosis.

Purpose of the Study:

• To investigate the dynamic correlations between red blood markers and inflammatory indicators in polytrauma-induced sepsis/septic shock.
• To elucidate the mechanisms underlying anemia in this patient population.
• To provide insights for improved management of hypoxemic changes and patient outcomes.

Main Methods:

• Studied dynamic correlations of red blood markers and inflammatory indicators in 21 adult polytrauma-induced septic shock patients over 45 days post-admission.
• Utilized Pearson correlation analysis for data interpretation.
• Patients were treated according to International Guidelines for Management of Severe Sepsis and Septic Shock.

Main Results:

• Initial anemia correlated with trauma-induced hemorrhage and surgical interventions.
• Decreased red blood markers showed a negative correlation with elevated systemic inflammatory factors, indicating sepsis complications.
• During recovery, normalizing red blood markers correlated negatively with specific inflammatory factors.
• Fibrinogen, a non-specific inflammatory marker, strongly correlated with tissue oxygenation.
• Oxymetric parameters demonstrated correlations with inflammatory factor metabolites, with elevated fibrinogen positively correlating with tissue oxygenation quality.

Conclusions:

• Dynamic monitoring of red blood and inflammatory markers is essential in polytrauma sepsis.
• Fibrinogen levels are a significant indicator of tissue oxygenation quality in these patients.
• Understanding these correlations can guide therapeutic strategies and improve prognostic accuracy for polytrauma-induced sepsis/septic shock.