[COMPARATIVE EVALUATION OF THE TREATMENT OF VASOMOTOR RHINITIS IN PATIENTS WITH AND WITHOUT COVID-19 INFECTION]

Area of Science:

• Allergy and Immunology
• Otolaryngology
• Infectious Diseases

Background:

• Vasomotor rhinitis presents with diverse subjective and objective symptoms.
• The impact of prior COVID-19 infection on treatment outcomes for vasomotor rhinitis is not well-established.
• Local antihistamine therapy is a potential treatment modality for allergic and non-allergic rhinitis.

Purpose of the Study:

• To assess the efficacy of Palada NS, a local antihistamine, in treating vasomotor rhinitis.
• To compare treatment outcomes in patients with and without a history of COVID-19 infection.
• To evaluate the time course of symptom improvement with Palada NS treatment.

Main Methods:

• Diagnosis of vasomotor rhinitis based on comprehensive subjective and objective assessments.
• Treatment involved Palada NS (2 sprays, twice daily for 10 days) in both groups.
• Symptom and objective indicator assessments were conducted before, during (3-5 days), and after treatment.

Main Results:

• A majority of patients experienced significant improvement in subjective and objective complaints.
• Patients without COVID-19 history showed improvement by day 5.
• Patients with prior COVID-19 infection (≥6 months) showed improvement by the end of treatment.

Conclusions:

• Palada NS is a recommended treatment for vasomotor rhinitis, irrespective of COVID-19 infection history.
• The treatment regimen with Palada NS demonstrates effectiveness in alleviating vasomotor rhinitis symptoms.
• Prior COVID-19 infection may influence the speed of symptom resolution in vasomotor rhinitis patients.