Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Nonconscious Mimicry

Nonconscious Mimicry

Nonconscious mimicry occurs when individuals alter their mannerisms to match the behaviors and expressions of those nearby, without intention.

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

What Is in a Structure? Cell Permeability and Solubility of Series of Macrocycles and Linear Matched Pairs.

Journal of medicinal chemistry·2026

Same author

Exploiting a Cryptic Pocket in DsbA through Structure-Guided Parallel Synthesis and Direct-to-Biology Screening.

Journal of medicinal chemistry·2026

Same author

Ultra-large virtual screening unveils potent agonists of the neuromodulatory orphan receptor GPR139.

Nature communications·2025

Same author

NMR and SPR Fragment-Based Screening Can Produce Novel High Affinity Small Molecule Hits against Structured RNAs.

ACS chemical biology·2025

Same author

Discovery of a Cryptic Pocket in EcDsbA Opens New Opportunities for Antibacterial Discovery.

Angewandte Chemie (International ed. in English)·2025

Same author

Exploring the Ligandability of 53BP1 through Fragment-Based Approaches.

ACS medicinal chemistry letters·2025

Search research articles

Related Experiment Video

Updated: Feb 3, 2026

Author Spotlight: Exploring the Relationship Between Lipotoxicity and HFpEF

Author Spotlight: Exploring the Relationship Between Lipotoxicity and HFpEF

Published on: February 23, 2024

Cyclophilin Succumbs to a Macrocyclic Chameleon.

Bradley C Doak¹, Jan Kihlberg²

¹Department of Medicinal Chemistry, MIPS , Monash University , 381 Royal Parade , Parkville , Victoria 3052 , Australia.

Journal of Medicinal Chemistry

|October 26, 2018

Summary

Macrocycles derived from natural products offer a promising strategy for developing drugs against challenging targets like cyclophilin. Sanglifehrin A was successfully modified to create an orally bioavailable drug candidate.

More Related Videos

Preparation and In Vitro Characterization of Dendrimer-based Contrast Agents for Magnetic Resonance Imaging

Preparation and In Vitro Characterization of Dendrimer-based Contrast Agents for Magnetic Resonance Imaging

Published on: December 4, 2016

Study of Viral Vectors in a Three-dimensional Liver Model Repopulated with the Human Hepatocellular Carcinoma Cell Line HepG2

Study of Viral Vectors in a Three-dimensional Liver Model Repopulated with the Human Hepatocellular Carcinoma Cell Line HepG2

Published on: October 24, 2016

Related Experiment Videos

Last Updated: Feb 3, 2026

Author Spotlight: Exploring the Relationship Between Lipotoxicity and HFpEF

Author Spotlight: Exploring the Relationship Between Lipotoxicity and HFpEF

Published on: February 23, 2024

Preparation and In Vitro Characterization of Dendrimer-based Contrast Agents for Magnetic Resonance Imaging

Preparation and In Vitro Characterization of Dendrimer-based Contrast Agents for Magnetic Resonance Imaging

Published on: December 4, 2016

Study of Viral Vectors in a Three-dimensional Liver Model Repopulated with the Human Hepatocellular Carcinoma Cell Line HepG2

Study of Viral Vectors in a Three-dimensional Liver Model Repopulated with the Human Hepatocellular Carcinoma Cell Line HepG2

Published on: October 24, 2016

Area of Science:

Medicinal Chemistry
Drug Discovery
Organic Synthesis

Background:

Large, groove-shaped binding sites, exemplified by cyclophilin, present significant challenges for small molecule drug development.
Natural product macrocycles possess unique structural features suitable for targeting such challenging binding pockets.

Purpose of the Study:

To explore the potential of natural product-derived macrocycles as starting points for drug discovery against difficult targets.
To demonstrate the optimization of a macrocycle, sanglifehrin A, into an orally bioavailable drug candidate.

Main Methods:

Development of convergent and modular synthetic routes for macrocycle modification.
Application of structure- and property-based methods for lead optimization.

Main Results:

Successful transformation of sanglifehrin A into a potential drug candidate with oral bioavailability.
Demonstration of enhanced drug-like properties through optimized synthesis and structure-based design.

Conclusions:

Natural product macrocycles are valuable scaffolds for developing therapeutics against challenging targets.
Integrated approaches combining advanced synthesis and rational design are crucial for successful lead optimization.