Related Experiment Video
Updated: Feb 3, 2026
05:18
A Protocol for Constructing a Rat Wound Model of Type 1 Diabetes
Published on: February 17, 2023
5.8K
Preserved endothelial function in young adults with type 1 diabetes
Martin Heier1,2,3, Cathrine Nygaard Espeland4, Cathrine Brunborg5
1Pediatric Department, Oslo University Hospital, Oslo, Norway.
Plos One
|October 26, 2018
Summary
Young adults with type 1 diabetes (T1D) show preserved endothelial function, measured by reactive hyperemia index (RHI), compared to healthy peers. This suggests T1D does not impair vascular health in this age group.
Area of Science:
- Cardiovascular Health
- Endocrinology
- Vascular Biology
Background:
- Endothelial dysfunction is a key factor in atherosclerosis, often seen in older adults with type 1 diabetes (T1D).
- The impact of T1D on endothelial function in young adults requires further investigation.
Purpose of the Study:
- To evaluate endothelial function in young adults with T1D using peripheral arterial tonometry (PAT).
- To examine the relationship between endothelial function, cardiovascular risk factors, and long-term glycemic control in T1D patients.
Main Methods:
- Assessed endothelial function via reactive hyperemia index (RHI) using PAT in 46 T1D patients and 32 controls.
- Utilized data from the "Atherosclerosis and Childhood Diabetes" study and Norwegian Childhood Diabetes Registry for HbA1c measurements.
Main Results:
- No significant difference in RHI was observed between T1D patients (mean 2.00) and controls (mean 2.21).
- No associations were found between RHI and traditional risk factors, gender, HbA1c, or long-term glycemic burden.
Conclusions:
- Endothelial function, as measured by RHI, is preserved in young adults with type 1 diabetes.
- Early T1D does not appear to negatively impact endothelial function in this cohort.
More Related Videos
Related Concept Videos
01:22Diabetes Mellitus: Type 2 and Gestational
5.0K
Type 2 diabetes, characterized by insulin resistance, arises when the insulin receptors on cells lose responsiveness to insulin, diminishing the cell's capacity to take up glucose, resulting in elevated blood glucose levels. To receive a diagnosis of Type 2 diabetes, a series of blood glucose tests are necessary to assess whether the blood glucose falls within normal parameters. If the result is out of the normal range, a patient may be diagnosed as prediabetic or diabetic, depending on the...
5.0K
01:26Types of Functions I
308
Functions are fundamental mathematical tools that capture relationships between variables and describe how one quantity changes in relation to another. Their diverse forms allow them to model various real-world phenomena with precision and flexibility. Among the various categories, algebraic functions are prominent due to their formulation through basic arithmetic operations: addition, subtraction, multiplication, division, and root extraction.Algebraic functions include polynomial, rational,...
308
01:22Diabetes Mellitus: Overview and Type I Subtype
5.4K
Diabetes mellitus is a chronic metabolic disorder characterized by high blood glucose levels due to inadequate insulin production, insulin resistance, or both. The condition affects millions worldwide and can significantly impact their health and quality of life.
Type 1 diabetes is an autoimmune disease in which the immune system mistakenly attacks and destroys the insulin-producing beta cells in the pancreas. As a result, the body is unable to produce sufficient insulin, and individuals with...
Type 1 diabetes is an autoimmune disease in which the immune system mistakenly attacks and destroys the insulin-producing beta cells in the pancreas. As a result, the body is unable to produce sufficient insulin, and individuals with...
5.4K
01:19Types of Functions II
191
Trigonometric and exponential functions are essential mathematical tools used to model distinct types of real-world behavior, particularly in periodic and growth-related phenomena. These functions extend the capabilities of basic algebraic models by capturing recurring cycles and rapid changes across various scientific and engineering contexts.Trigonometric functions, such as sine and cosine, are particularly effective for representing periodic phenomena. Their cyclic behavior makes them...
191
01:24T Cell Types and Functions
2.5K
When T cells with CD4 markers are activated, they give rise to two types of effector cells: helper T cells and regulatory T cells. Meanwhile, T cells with CD8 markers differentiate into effector cytotoxic T cells. The differentiation of CD4 T cells into helper T cell subsets, such as Th1, Th2, and Th17 cells, is dependent on the antigen type, antigen-presenting cell, and regulatory cytokines.
Th1 cells stimulate dendritic cells to express necessary co-stimulatory molecules on their surfaces for...
Th1 cells stimulate dendritic cells to express necessary co-stimulatory molecules on their surfaces for...
2.5K
01:28Types of Functions III
264
Logarithmic and piecewise functions play central roles in mathematical modeling, particularly when capturing nonlinear or segmented behaviors in real-world phenomena. Although these functions differ fundamentally in structure and application, both serve to represent complex relationships in simplified mathematical terms.A logarithmic function is defined as the inverse of an exponential function, expressed as These functions grow quickly for small values of x but slow down as x increases,...
264