Related Experiment Video
Updated: Feb 3, 2026

Synthesis and Characterization of Functionalized Metal-organic Frameworks
Published on: September 5, 2014
Development of Biocompatible Iron-Carboxylate Metal Organic Frameworks for pH-Responsive Drug Delivery Application
Vandana Gupta1, Sachin Tyagi1, A K Paul2
1CSIR-Central Scientific Instruments Organization, Chandigarh 160030, India.
Abstract:
Metal organic frameworks (MOFs), MIL-101-Fe (Materials of Institute Lavoisier), have been synthesized by solvothermal method. The as-synthesized MIL-101-Fe particles are observed to have hexagonal shaped morphology with average particle size ranging from 480 to 500 nm. The functionalization of the surface of as-synthesized MIL-101-Fe particles was done with the integration of amine group into the framework to facilitate the conjugation of the drug and other entities. Further, the drug conjugated MOF particles were coated with polyethyleneglycol (PEG) layer so as to extend the drug release time by controlling the faster pH mediated MOF degradation in biological buffers. pH dependent drug release study of the MOF particles was carried out at 3 different pH values, i.e., 5, 6 and 7.4. The drug release profiles showed that the drug released from NH₂-MIL-101-Fe takes less time which was further increased after coating the NH₂-MIL-101-Fe with polyethyleneglycol (PEG@Drug@NH₂-MIL-101-Fe). This confirmed that PEG coated particles have great stability for drug delivery application.
More Related Videos
08:25Development of Heterogeneous Enantioselective Catalysts using Chiral Metal-Organic Frameworks MOFs
Published on: January 17, 2020
12:05Preparation of Hydrophobic Metal-Organic Frameworks via Plasma Enhanced Chemical Vapor Deposition of Perfluoroalkanes for the Removal of Ammonia
Published on: October 10, 2013
Related Concept Videos
Organic Compounds
Drug Delivery: Overview
Enteral delivery involves administering drugs directly through swallowing, sublingual placement, or buccal application. Orally administered drugs predominantly navigate the...
Drug Delivery: Enteral Route
Drug Delivery: Parenteral Route
There are three primary parenteral routes: intravenous (IV), intramuscular (IM), and subcutaneous (SC). The IV route introduces the drug directly into the bloodstream, ensuring immediate action. The IM route...
Drug Delivery: Miscellaneous Routes
Oral inhalation and nasal sprays swiftly transfer drugs across the respiratory epithelium's mucosal layer. Inhaled glucocorticoids and bronchodilators directly target lung conditions such as asthma, while fluticasone nasal spray mitigates allergic rhinitis.
Transdermal patches transport drugs...
Development of the Sexual Organs in the Embryo and Fetus
Near the gonadal ridges, two duct systems are present: the mesonephric ducts (Wolffian ducts) and paramesonephric ducts (Müllerian ducts). These ducts form the basis for the...