Different Cellular Effects of Platinum Nanoparticles on RAW 264.7 Cells
Ta Thi Loan1, Le Thanh Do2, Hoon Yoo3
1Institute of Biotechnology, Vietnam Academy of Science and Technology, Hanoi, 10000, Vietnam.
Abstract:
The cellular effects of platinum nanoparticle (PtNP) and platinum nanocolloid (PtNC) were investigated on murine leukemia Raw 264.7 cells. PtNP induced strong cytotoxic effects on Raw 264.7 cells while PtNC showed only mild cytotoxicity. Dramatic reduction in cell growth and morphological changes were observed for cells treated with PtNPs while PtNC did not show these effects. Both PtNPs and PtNC suppressed nitric oxide production, but PtNPs were superior to PtNC. PtNP strongly suppressed the expression of iNOS, COX-2 proteins and the phosphorylation of AKT on LPS-stimulated Raw 264.7 cells while PtNC showed only weak effects on these proteins. Our data showed that the preparation method of platinum nanoparticles may cause different cellular effects on cell growth and signaling.
More Related Videos
Related Concept Videos
Biological Effects of Radiation
Buffer Effectiveness
The buffer capacity is the amount of acid or base that can be added to a given volume...
Framing Effects
Cellular Differentiation
A zygote is a...
Cellular Respiration
Introduction to Cellular Respiration
ATP stores energy in chemical bonds that can be quickly released when needed. Cells produce energy in the form of ATP through the process of cellular respiration. Although much of the energy from cellular respiration is released as heat, some of it is used to make ATP.
During cellular respiration, several...


