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Updated: Feb 3, 2026

Inducible and Reversible Dominant-negative DN Protein Inhibition
Published on: January 7, 2019
The Dominant Role of Forkhead Box Proteins in Cancer
Duc-Hiep Bach1, Nguyen Phuoc Long2, Thi-Thu-Trang Luu3
1College of Pharmacy, Seoul National University, Seoul 08826, Korea. bdhiep90@snu.ac.kr.
Abstract:
Forkhead box (FOX) proteins are multifaceted transcription factors that are significantly implicated in cancer, with various critical roles in biological processes. Herein, we provide an overview of several key members of the FOXA, FOXC, FOXM1, FOXO and FOXP subfamilies. Important pathophysiological processes of FOX transcription factors at multiple levels in a context-dependent manner are discussed. We also specifically summarize some major aspects of FOX transcription factors in association with cancer research such as drug resistance, tumor growth, genomic alterations or drivers of initiation. Finally, we suggest that targeting FOX proteins may be a potential therapeutic strategy to combat cancer.
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