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In Vivo Inhibition of MicroRNA to Decrease Tumor Growth in Mice
Published on: August 23, 2019
Tumor Targeting and Tumor Growth Inhibition Capability of Mesoporous Silica Nanoparticles in Mouse Models
Tan Le Hoang Doan1, Ngoc Xuan Dat Mai2, Kotaro Matsumoto3
1Institute for Integrated Cell-Material Sciences, Institute for Advanced Study, Kyoto University, Kyoto, Japan; Center for Innovative Materials and Architectures (INOMAR), University of Science, Vietnam National University-Ho Chi Minh City, Ho Chi Minh City, Vietnam; Faculty of Chemistry, University of Science, Vietnam National University-Ho Chi Minh City, Ho Chi Minh City, Vietnam.
Abstract:
Mesoporous silica nanoparticles (MSNs) provide a promising vehicle for anticancer drug delivery. Various animal studies point to the efficacy of this nanoparticle for delivering anticancer agents (drug and siRNA) to inhibit tumor growth. These studies also showed tumor accumulation of MSN nanoparticles. While the extent of tumor accumulation differed, the study showed that it is possible to achieve significant accumulation of nanoparticles in the tumor. Biocompatibility and safety of MSN were also demonstrated by these studies.
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