Microperimetry and multimodal imaging in polypoidal choroidal vasculopathy.

Area of Science:

• Ophthalmology
• Medical Imaging
• Retinal Diseases

Background:

• Polypoidal choroidal vasculopathy (PCV) is a significant cause of vision loss.
• Accurate assessment of PCV extent is crucial for treatment planning and monitoring.
• Evaluating topographical concordance between different diagnostic modalities is essential.

Purpose of the Study:

• To determine the topographical concordance in the areal extent of PCV using indocyanine green angiography (ICGA), spectral-domain optical coherence tomography (SD-OCT), and microperimetry.
• To compare the outcomes from these modalities after anti-vascular endothelial growth factor treatment.

Main Methods:

• The study included 25 individuals (25 eyes) with PCV treated with anti-VEGF therapy.
• Indocyanine green angiography (ICGA) defined the PCV extent.
• Spectral-domain optical coherence tomography (SD-OCT) and microperimetry assessed structural and functional changes, respectively.
• Pattern Deviation probability analysis evaluated differential light sensitivity.

Main Results:

• Overall concordance in areal extent between ICGA, SD-OCT, and microperimetry was 59%.
• Median concordance was 60% (ICGA/microperimetry), 70% (ICGA/SD-OCT), and 72% (SD-OCT/microperimetry).
• SD-OCT and microperimetry identified greater areas of abnormality than ICGA in a significant number of eyes, supporting SD-OCT's clinical utility.

Conclusions:

• Strong concordance exists between SD-OCT and microperimetry in assessing PCV.
• Microperimetry identified additional areas of functional abnormality not detected by SD-OCT.
• SD-OCT is clinically useful for evaluating PCV extent, complementing ICGA findings.