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A Comprehensive Protocol for Manual Segmentation of the Medial Temporal Lobe Structures
Published on: July 2, 2014
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Medial temporal lobe functional connectivity predicts stimulation-induced theta power
E A Solomon1, J E Kragel2, R Gross3
1Department of Bioengineering, University of Pennsylvania, Philadelphia, PA, 19146, USA. esolo@pennmedicine.upenn.edu.
Nature Communications
|October 27, 2018
Summary
Brain stimulation can control neural networks. Functional connectivity networks predict how electrical stimulation changes brain activity, paving the way for clinical applications.
Area of Science:
- Neuroscience
- Computational Neuroscience
- Systems Neuroscience
Background:
- Electrical stimulation of the brain can modulate neural activity and offers therapeutic potential.
- Understanding how electrical signals interact with human brain networks is crucial for clinical translation.
- Medial temporal lobe plays a key role in memory and emotion processing and is a target for neuromodulation.
Purpose of the Study:
- To investigate how focal electrical stimulation affects brain networks in humans.
- To determine if functional connectivity predicts stimulation-evoked neural activity.
- To explore the relationship between stimulation parameters and network responses.
Main Methods:
- Electrical stimulation was applied to subregions of the medial temporal lobe in 26 neurosurgical patients with indwelling electrodes.
- Low-frequency (5-13 Hz) spectral coherence was used to predict stimulation-evoked changes in theta (5-8 Hz) power.
- High-frequency broadband (HFB; 50-200 Hz) power modulations were analyzed and correlated with HFB-based networks.
Main Results:
- Networks of low-frequency spectral coherence predicted stimulation-evoked increases in theta power, especially when stimulation targeted white matter.
- Electrical stimulation generally decreased HFB power.
- HFB power modulations were correlated with HFB-based networks in some subjects.
Conclusions:
- Functional connectivity is predictive of causal changes in brain activity induced by electrical stimulation.
- This study demonstrates that pre-stimulation functional networks can anticipate evoked activity across different brain regions and frequency bands.
- Findings support the use of functional connectivity to guide and predict the effects of brain stimulation for therapeutic purposes.
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