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Dehydration Status Predicts Short-Term and Long-Term Outcomes in Patients with Cerebral Venous Thrombosis

Kai Liu1, Lulu Pei1, Yuan Gao1

  • 1Department of Neurology, The First Affiliated Hospital of Zhengzhou University, No.1 Eastern Jianshe Road, Zhengzhou, 450052, Henan, China.

Neurocritical Care
|October 27, 2018
PubMed

Insights

Dehydration is linked to worse outcomes in cerebral venous thrombosis (CVT) patients. This study found dehydration independently predicts poor short-term and long-term functional outcomes and increased mortality in CVT.

Area of Science:

  • Neurology
  • Vascular Medicine
  • Clinical Research

Background:

  • Dehydration is a known risk factor for poor outcomes in acute ischemic stroke.
  • The prognostic impact of dehydration in cerebral venous thrombosis (CVT) remains under-investigated.

Purpose of the Study:

  • To investigate the association between dehydration and prognosis in patients diagnosed with cerebral venous thrombosis (CVT).

Main Methods:

  • Retrospective analysis of 220 CVT patients (November 2011-January 2017).
  • Dehydration assessed using blood urea/creatinine (U/Cr) ratio > 80.
  • Poor functional outcome defined as modified Rankin Scale (mRS) 3-6.
  • Multivariate logistic and Cox regression analyses adjusted for clinical factors.

Main Results:

  • 38.64% of CVT patients exhibited dehydration.
  • Dehydration independently predicted poor short-term (mRS 3-6 at discharge) and long-term functional outcomes.
  • Dehydration was associated with significantly higher mortality (adjusted HR 2.301).

Conclusions:

  • Dehydration is an independent predictor of unfavorable functional outcomes in CVT patients.
  • Findings highlight the importance of monitoring hydration status in CVT management.
  • Early identification and management of dehydration may improve CVT patient prognosis.
Abstract

Keywords:
Blood urea/creatinine ratioCerebral venous thrombosisDehydrationMortalityPrognosisRisk factors

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