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Updated: Feb 3, 2026

Kinetic Screening of Nuclease Activity using Nucleic Acid Probes
Published on: November 1, 2019
Piptolinic acids F-J, five new lanostane-type triterpenoids from Piptoporus betulinus
Qosimjon Khalilov1,2, Liya Li3, Yushuang Liu1,2
1The Key Laboratory of Plant Resources and Chemistry of Arid Zone, and State Key Laboratory of Xinjiang Indigenous Medicinal Plants Resource Utilization, Xinjiang Technical Institute of Physics and Chemistry, Chinese Academy of Sciences , Urumqi , China.
Abstract:
Five new lanostane-type triterpenoids, named piptolinic acids F - J (1-5), as well as seven known analogues (6-12), were isolated from methanolic extract of the fruiting bodies of Piptoporus betulinus. Compounds 1-4 were 24-methyl-lanostane triterpenoids, while compound 5 was a 3,4-seco-lanostane derivative. Their structures were established on the basis of extensive spectroscopic analysis (1D, 2D NMR, and HRESIMS). Cytotoxicity evaluation indicated that compound 6 exhibited moderate cytotoxic activity against human melanoma cell line A-375 (IC50 = 42.8 μM) and human renal carcinoma cell line 786-O (IC50 = 56.5 μM).
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