Related Experiment Video
Updated: Feb 3, 2026

Synthesis and Characterization of Functionalized Metal-organic Frameworks
Published on: September 5, 2014
A biocompatible metal-organic framework as a pH and temperature dual-responsive drug carrier
Wenxin Lin1, Yuanjing Cui, Yu Yang
1Department of Materials Engineering, College of Materials and Textile, Zhejiang Sci-Tech University, Hangzhou 310018, PR China. linwx@zstu.edu.cn.
Abstract:
A biocompatible metal-organic framework Zn-GA comprising zinc ions and the bio-friendly molecule l-glutamic acid (GA) is synthesized as a drug delivery system, and controlled drug release triggered by pH and thermal stimuli without premature delivery is realized. The anticancer drug methotrexate (MTX) is selected to be encapsulated into the crystal which possesses one-dimensional channels along the a axis. The on-command drug carrier shows superior biocompatibility, extremely low toxicity, satisfactory loading capabilities and excellent dual-responsiveness, indicating its practical application as an efficient drug carrier with controlled release.
More Related Videos
Related Concept Videos
Electron Carriers
Over the many stages of cellular respiration, glucose breaks down into carbon dioxide and water. Electron carriers pick up electrons lost by glucose in these reactions, temporarily storing and releasing them into the electron...
Drug Absorption Mechanism: Carrier-Mediated Membrane Transport
Facilitated diffusion is a passive process that utilizes human Solute Carrier (SLC) transporters. These transporters bind to the drug, undergo structural...
Factors Affecting Drug Response: Overview
Bonding in Metals
Metallic Solids
All metallic solids exhibit high thermal and electrical conductivity, metallic luster, and malleability....
Carrier Transport
Drift Current:
The drift of charge carriers is started by an external electric field (E). Charged particles, such as electrons and holes, experience an acceleration between collisions with lattice atoms. For electrons, this results in a drift velocity (vd) given by:

