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Updated: Feb 3, 2026

Capillary Electrophoresis Separation of Monoclonal Antibody Isoforms Using a Neutral Capillary
Published on: January 16, 2017
Recent advances in enhancing the sensitivity of electrophoresis and electrochromatography in capillaries and
Michael C Breadmore1, Wojciech Grochocki1,2, Umme Kalsoom1,3
1Australian Centre for Research on Separation Science, Chemistry, School of Natural Science, University of Tasmania, Hobart, Tasmania, Australia.
Abstract:
One of the most cited limitations of capillary and microchip electrophoresis is the poor sensitivity. This review continues to update this series of biannual reviews, first published in Electrophoresis in 2007, on developments in the field of online/in-line concentration methods in capillaries and microchips, covering the period July 2016-June 2018. It includes developments in the field of stacking, covering all methods from field-amplified sample stacking and large-volume sample stacking, through to isotachophoresis, dynamic pH junction, and sweeping. Attention is also given to online or in-line extraction methods that have been used for electrophoresis.
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