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Updated: Feb 3, 2026

Process Optimization using High Throughput Automated Micro-Bioreactors in Chinese Hamster Ovary Cell Cultivation
Published on: May 18, 2020
A Fully Automated High-Throughput Bioreactor System for Lung Regeneration
Daniel E Gorman1, Tong Wu1,2, Sarah E Gilpin1,2
11 Center for Regenerative Medicine , Massachusetts General Hospital, Boston, Massachusetts.
Impact Statement:
This work presents methods for ex vivo lung recellularization and biomimetic culture in a high-throughput and consistent manner. These methods allow for the testing of multiple variables, all of which are simultaneously controlled and monitored on a single fully automated pump system, and subsequent assessment of both epithelial and endothelial repair and tissue regeneration. This system provides a controlled environment for tissue repair, wherein key variables can be modified, monitored, reproduced, and optimized to advance the goal of ex vivo tissue regeneration based on native organ scaffolds.
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