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Evaluation of Angiogenesis in Colorectal Cancer
I C Deliu1, P Ciurea2, D Neagoe1
1Department of Gastroenterology, University of Medicine and Pharmacy of Craiova, Romania.
Current Health Sciences Journal
|October 27, 2018
Summary
This study compared CD31, CD34, and CD105 antibodies for assessing tumor angiogenesis. CD34 identified more vessels than CD31 or CD105, highlighting neoangiogenesis importance in colorectal cancer treatment.
Area of Science:
- Oncology
- Vascular Biology
- Immunohistochemistry
Background:
- Angiogenesis, the formation of new blood vessels, is crucial for tumor growth and progression.
- Assessing neoangiogenesis aids in understanding tumor behavior and selecting effective cancer therapies.
Purpose of the Study:
- To evaluate neoangiogenesis in colorectal adenocarcinoma using CD31, CD34, and CD105 antibodies.
- To compare the efficacy of CD31, CD34, and CD105 in quantifying microvascular density (MVD) and identifying neoformation vessels.
Main Methods:
- Microvascular density (MVD) was quantified by counting blood vessels stained with CD31, CD34, and CD105 per square millimeter.
- CD105 was used to specifically determine neoformation (angiogenic) blood vessels.
- CD31 and CD34 served as control markers to differentiate between neoformation and mature vessels.
Main Results:
- Student t-tests revealed significantly higher MVD when using CD34 compared to CD31 and CD105 (p<0.001).
- A statistically significant direct correlation was observed between CD31 and CD105 (Pearson correlation coefficient r=0.440, p=0.0013).
Conclusions:
- Approximately 40% of tumor vasculature in colorectal adenocarcinoma consists of neoformation vessels.
- Accurate assessment of neoangiogenesis is vital for selecting appropriate and effective cancer treatments.
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