Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Video

Updated: Feb 3, 2026

Genetic Analysis of Hereditary Transthyretin Ala97Ser Related Amyloidosis
06:33

Genetic Analysis of Hereditary Transthyretin Ala97Ser Related Amyloidosis

Published on: June 9, 2018

8.1K

Amyloidosis Presenting with Macroglossia.

Amir Shahbaz1, Kashif Aziz2, Muhammad Umair3

  • 1Internal Medicine, Icahn School of Medicine at Mount Sinai/Queens Hospital Center, New York, USA.

Cureus
|October 27, 2018
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Letter to the Editor: "Magnesium-Rich Mineral Water Improves Stool Consistency and Bowel Habits in Healthy Subjects: A Randomized Controlled Trial".

Neurogastroenterology and motility·2026
Same author

Blood-nulled late gadolinium enhancement increases sensitivity for subtle basal myocardial scar in mitral valve prolapse with annular disjunction.

Radiology case reports·2026
Same author

Magnetic Particle Imaging for Pulmonary Applications: Technological Advances, Biological Insights, and Clinical Translation.

Bioengineering (Basel, Switzerland)·2026
Same author

A novel loss-of-function variant in DNHD1 linked to human asthenozoospermia.

Clinical and experimental reproductive medicine·2026
Same author

Targeting the tumor microenvironment in glioblastoma: Mechanistic insights, therapeutic strategies, and advances in immunotherapy.

Life sciences·2026
Same author

Visual deep learning approaches for alphabetic sign language interpretation.

Scientific reports·2026
Same journal

Immunohistochemistry (IHC) Versus Genomic Profiling in Cancer: Roles in Precision Medicine.

Cureus·2026
Same journal

Pediatric Nasal Tip Reconstruction After a Donkey Bite Using an Expanded Paramedian Forehead Flap With Conchal Cartilage Grafts: A Case Report.

Cureus·2026
Same journal

Splenic Rupture: A Delayed and Rare Complication of Colonoscopy.

Cureus·2026
Same journal

Super-refractory Status Epilepticus in Febrile Infection-Related Epilepsy Syndrome Triggered by Influenza A: A Pediatric Case Report.

Cureus·2026
Same journal

Comparative Evaluation of Serum Peroxiredoxin 2 (PRDX2), Serum Peroxiredoxin 4 (PRDX4), and Plasma Methylated Septin 9 (mSEPT9) Levels Against Conventional Biomarkers for Early Detection of Colorectal Cancer: A Study Protocol.

Cureus·2026
Same journal

Inspiratory Muscle Training for Patients With Chronic Obstructive Pulmonary Disease: A Narrative Review.

Cureus·2026
See all related articles

This case study highlights a 67-year-old patient with macroglossia and amyloidosis, presenting with tongue ulcerations and swallowing difficulties. The findings suggest a link between these conditions, prompting further investigation into underlying causes.

Area of Science:

  • Internal Medicine
  • Pathology

Background:

  • Macroglossia, an enlarged tongue, can cause significant functional and cosmetic issues.
  • Amyloidosis is a rare condition involving abnormal protein buildup in organs.

Observation:

  • A 67-year-old female with a history of vitamin B12 deficiency presented with macroglossia, tongue ulcerations, and dysphagia.
  • Elevated C-reactive protein (CRP) and low complement 3 (C3) levels were noted.
  • Gastrointestinal bleeding and gastric thickening suspicious for malignancy were observed.

Findings:

  • Tongue biopsy confirmed amyloidosis.
  • The patient's presentation suggests a complex interplay between macroglossia, amyloidosis, and potential gastrointestinal pathology.

Implications:

Keywords:
amyloidosismacroglossia

More Related Videos

Performing and Processing FNA of Anterior Fat Pad for Amyloid
09:41

Performing and Processing FNA of Anterior Fat Pad for Amyloid

Published on: October 30, 2010

56.2K
Rapid, Affordable, and Uncomplicated Production of Bacterial Cell-free Lysate
06:03

Rapid, Affordable, and Uncomplicated Production of Bacterial Cell-free Lysate

Published on: October 29, 2021

5.1K

Related Experiment Videos

Last Updated: Feb 3, 2026

Genetic Analysis of Hereditary Transthyretin Ala97Ser Related Amyloidosis
06:33

Genetic Analysis of Hereditary Transthyretin Ala97Ser Related Amyloidosis

Published on: June 9, 2018

8.1K
Performing and Processing FNA of Anterior Fat Pad for Amyloid
09:41

Performing and Processing FNA of Anterior Fat Pad for Amyloid

Published on: October 30, 2010

56.2K
Rapid, Affordable, and Uncomplicated Production of Bacterial Cell-free Lysate
06:03

Rapid, Affordable, and Uncomplicated Production of Bacterial Cell-free Lysate

Published on: October 29, 2021

5.1K
  • This case underscores the importance of investigating macroglossia for underlying systemic diseases like amyloidosis.
  • Early diagnosis and management are crucial for patients presenting with these combined symptoms.